Comparison of the Genital Microbiomes of Pregnant Aboriginal and Non-aboriginal Women.

Frontiers in Cellular and Infection Microbiology
Nicole K DinsdaleGeorge L Mendz

Abstract

The genital microbiomes of women varies with racial background. Preterm birth and early-onset neonatal sepsis are two outcomes associated with genital infections during pregnancy. The rate of preterm birth in Aboriginal Australian mothers is high, as is the rate of early-onset sepsis in their infants. To date, no studies have been conducted to investigate genital microbiome taxa associated infection in this group of women. A prospective cohort study to characterize the vaginal and placental microbiomes of a group of these women from the Pilbara region was conducted at the Hedland Health Campus in Western Australia. Included in the study were gravidae Aboriginal (n = 23) and Non-aboriginal (n = 27) women in labor or for planned lower uterine segment Caesarean section. Employing sterile swabs, vaginal samples were obtained under sterile conditions immediately prior to vaginal delivery or planned Caesarean section; and placental samples were obtained under the same conditions during labor. Taxa present in the samples were identified by 16S rRNA amplicon sequencing (V4 region, 515F-806R). Taxon identity and abundance were established from Operational Taxonomic Unit (OTU) counts. Statistical analyses combining clinical metadata and ...Continue Reading

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Citations

Aug 30, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Kiarna BrownHolger W Unger

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Datasets Mentioned

BETA
PRJEB39698

Methods Mentioned

BETA
amplicon sequencing
Illumina sequencing

Software Mentioned

PERMDISP
MiSeq
MaAsLIN
Mothur
Galaxy
LEfSe
Primer
distLM
Statistical Package for the Social Sciences ( SPSS )

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