Comparison of the genome sequences of non-pathogenic and pathogenic African swine fever virus isolates

The Journal of General Virology
David A G ChapmanL K Dixon

Abstract

The genomic coding sequences, apart from the inverted terminal repeats and cross-links, have been determined for two African swine fever virus (ASFV) isolates from the same virus genotype, a non-pathogenic isolate from Portugal, OURT88/3, and a highly pathogenic isolate from West Africa, Benin 97/1. These genome sequences were annotated and compared with that of a tissue culture-adapted isolate, BA71V. The genomes range in length between 170 and 182 kbp and encode between 151 and 157 open reading frames (ORFs). Compared to the Benin 97/1 isolate, the OURT88/3 and BA71V isolates have deletions of 8-10 kbp that encode six copies of the multigene family (MGF) 360 and either one MGF 505/530 copy in the BA71V or two copies in the OURT88/3 isolate. The BA71V isolate has a deletion, close to the right end of the genome, of 3 kbp compared with the other isolates. The five ORFs in this region include an additional copy of an ORF similar to that encoding the p22 virus structural protein. The OURT88/3 isolate has interruptions in ORFs that encode a CD2-like and a C-type lectin protein. Variation between the genomes is observed in the number of copies of five different MGFs. The 109 non-duplicated ORFs conserved in the three genomes encode...Continue Reading

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Citations

Aug 19, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Solenne CostardLinda K Dixon
Jan 11, 2011·Transboundary and Emerging Diseases·G MisinzoH J Nauwynck
Dec 26, 2008·Journal of Virology·Christopher L NethertonGeraldine Taylor
Oct 23, 2009·Journal of Virology·Cristina SuárezJavier M Rodríguez
Jul 5, 2008·Genome Biology·Adam MonierHiroyuki Ogata
Apr 8, 2011·Emerging Infectious Diseases·David A G ChapmanLinda K Dixon
Jan 5, 2011·Archives of Virology·V L de OliveiraR M E Parkhouse
Jan 15, 2013·Virus Research·Iván Galindo-CardielJoaquim Segalés
Nov 13, 2012·Virus Research·Linda K DixonChris Upton
Nov 6, 2012·Virus Research·S CostardD U Pfeiffer
Oct 9, 2012·Virus Research·Javier M Rodríguez, Maria L Salas
Jun 10, 2015·Virus Research·Raquel Muñoz-MorenoCovadonga Alonso
Dec 20, 2014·The Journal of General Virology·A MalogolovkinD L Rock
Nov 20, 2014·The Journal of General Virology·Raquel PortugalGünther M Keil
Nov 5, 2013·Virus Research·Modesto Redrejo-Rodríguez, María L Salas
Apr 29, 2015·PloS One·Daniel Pérez-NúñezRicardo Madrid
Aug 3, 2016·Transboundary and Emerging Diseases·P D LukaJ Erume
Aug 30, 2016·Antiviral Research·Ferdinando B FreitasFernando Ferreira
Sep 8, 2016·Veterinary Microbiology·Magdalena FrączykZygmunt Pejsak
Apr 25, 2017·Scientific Reports·Manuel V BorcaDouglas P Gladue
Oct 11, 2017·Vaccines·Marisa AriasUNKNOWN Sanchez-Vizcaino
Jul 31, 2019·The Journal of General Virology·Alexandra HübnerWalter Fuchs
Sep 21, 2019·Transboundary and Emerging Diseases·Teshale TeklueHua-Ji Qiu
Apr 16, 2020·Database : the Journal of Biological Databases and Curation·Zhenglin Zhu, Geng Meng

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