Comparison of the Incorporation of DHA in Circulatory and Neural Tissue When Provided as Triacylglycerol (TAG), Monoacylglycerol (MAG) or Phospholipids (PL) Provides New Insight into Fatty Acid Bioavailability

Nutrients
Frédéric DestaillatsCristina Cruz-Hernandez

Abstract

Phospholipids (PL) or partial acylglycerols such as sn-1(3)-monoacylglycerol (MAG) are potent dietary carriers of long-chain polyunsaturated fatty acids (LC-PUFA) and have been reported to provide superior bioavailability when compared to conventional triacylglycerol (TAG). The main objective of the present study was to compare the incorporation of docosahexaenoic acid (DHA) in plasma, erythrocytes, retina and brain tissues in adult rats when provided as PL (PL-DHA) and MAG (MAG-DHA). Conventional dietary DHA oil containing TAG (TAG-DHA) as well as control chow diet were used to evaluate the potency of the two alternative DHA carriers over a 60-day feeding period. Fatty acid profiles were determined in erythrocytes and plasma lipids at time 0, 7, 14, 28, 35 and 49 days of the experimental period and in retina, cortex, hypothalamus, and hippocampus at 60 days. The assessment of the longitudinal evolution of DHA in erythrocyte and plasma lipids suggest that PL-DHA and MAG-DHA are efficient carriers of dietary DHA when compared to conventional DHA oil (TAG-DHA). Under these experimental conditions, both PL-DHA and MAG-DHA led to higher incorporations of DHA erythrocytes lipids compared to TAG-DHA group. After 60 days of supplement...Continue Reading

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Citations

Apr 10, 2020·Food & Function·Ronan LordanIoannis Zabetakis
Sep 17, 2020·The Journal of Nutrition·Chloé RobertMarie-Caroline Michalski
Sep 5, 2019·International Journal of Molecular Sciences·Amanda Lo VanNathalie Bernoud-Hubac
Feb 8, 2019·Frontiers in Neuroscience·Marilia Ferreira Frazão Tavares de MeloJuliana Késsia Barbosa Soares
Dec 29, 2020·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Koen ManusamaRenger Witkamp
Oct 9, 2020·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Regina F Fernandez, Jessica M Ellis
Nov 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bo-Ram Na, Jeung-Hee Lee
Aug 1, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Armond DaciGokce Topal
Jul 3, 2021·The International Journal of Neuropsychopharmacology·Wataru OmoriMinoru Takebayashi
Jul 18, 2021·Molecular Nutrition & Food Research·Inés Domínguez-LópezRosa M Lamuela-Raventós

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Methods Mentioned

BETA
nuclear magnetic resonance

Software Mentioned

R

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