PMID: 7581175Jul 1, 1995Paper

Comparison of the infection imaging properties of a 99mTc labeled chemotactic peptide with 111In IgG

Nuclear Medicine and Biology
J W BabichA J Fischman

Abstract

The biodistribution and infection imaging properties of a 99mTc labeled hydrazino nicotinamide (HYNIC) derivatized chemotactic peptide analog (For-Met-Leu-Phe-Lys-HYNIC) and 111In-DTPA-IgG were compared in rabbits with Escherichia coli infection. Six New Zealand white rabbits were injected in the left posterior thigh with a suspension of E. coli. Twenty four hours later, the animals were injected with: 1.0 mCi of 99mTc labeled peptide plus 0.1 mCi of 111In-DTPA-IgG. At 2-3 and 16-18 h, dual photon scintigrams were acquired and the images were corrected for crossover between the two windows. After recording the final images, the animals were sacrificed and biodistribution was determined. At both imaging times the biodistributions of the two reagents were markedly different. The highest concentrations of 111In-DTPA-IgG were detected in blood pool structures, liver and kidney. In contrast localization of 99mTc labeled peptide was greatest in spleen, lung and liver (consistent with binding to leukocytes). In general, the sites of infection were better visualized with the radiolabeled peptide and T/B ratios increased with time (P < 0.01). At both times, the T/Bs for 99mTc-peptide were higher (P < 0.01); 3.54 +/- 0.47 vs 2.52 +/- 0.3...Continue Reading

References

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Citations

Jan 12, 2002·Nuclear Medicine and Biology·Guozheng LiuDonald J Hnatowich
Jul 18, 2006·Nuclear Medicine and Biology·Yun-Sang LeeYoung-Ger Suh
Feb 28, 1998·The Orthopedic Clinics of North America·K J Donohoe
Oct 23, 2004·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·J K AmarteyR S Parhar
Jun 1, 1997·Human Nature : an Interdisciplinary Biosocial Perspective·J Constable
Mar 14, 2009·Chemical Communications : Chem Comm·Mark BartholomäJon Zubieta
Dec 26, 2001·Chemical Reviews·S Liu, D S Edwards

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