Abstract
We compared the effects of the two molecular forms of the brain-gut peptide YY (PYY), PYY(1-36) and PYY(3-36), on gastric emptying. Unanesthetized rats received 20-min intravenous infusions of rat PYY(1-36) (0, 1.7, 5, 17, 50, 100, 170 pmol x kg(-1) x min(-1)) and rat PYY(3-36) (0, 0.5, 1.7, 5, 17, 50, 100, 170 pmol x kg(-1) x min(-1)), either alone or combined, and gastric emptying of saline was measured during the last 10 min of infusion. For comparison, human PYY(3-36) was administered at 0, 17, and 50 pmol x kg(-1) x min(-1). Gastric emptying was decreased by 11, 24, 26 and 38% in response to 17, 50, 100, and 170 pmol x kg(-1) x min(-1) of rat PYY(1-36); by 10, 26, 41, 53, and 57% in response to 5, 17, 50, 100, and 170 pmol x kg(-1) x min(-1) of rat PYY(3-36); and by 35 and 53% in response to 17 and 50 pmol x kg(-1) x min(-1) of human PYY(3-36), respectively. Estimated ED50s were 470 and 37 pmol x kg(-1) x min(-1) for rat PYY(1-36) and PYY(3-36), respectively. In general, within an experiment, coadministration of PYY(1-36) and PYY(3-36) inhibited gastric emptying by an amount that was comparable to that produced when either peptide was given alone. We conclude that 1) intravenous infusion of PYY(1-36) and PYY(3-36) each pro...Continue Reading
References
Aug 24, 1992·Biochemical and Biophysical Research Communications·D GrandtH Goebell
Jan 1, 1990·Neuroscience·O HäppöläR Håkanson
Jul 1, 1986·The American Journal of Physiology·R D Reidelberger, T E Solomon
Dec 1, 1989·The American Journal of Physiology·J B MeddingsG H Fick
May 1, 1986·Endocrinology·M LaburtheB Amiranoff
Dec 22, 1986·Regulatory Peptides·R EkmanP Panula
Feb 1, 1987·Gut·A P SavageS R Bloom
Jun 1, 1986·Endocrinology·Y MiyachiK Tatemoto
Dec 1, 1986·Gastroenterology·T N PappasI L Taylor
Mar 1, 1985·Gastroenterology·I L Taylor
Nov 1, 1985·Gastroenterology·T E AdrianS R Bloom
Dec 1, 1985·Gastroenterology·T N PappasI L Taylor
Oct 1, 1985·Acta Physiologica Scandinavica·M BrooméL Terenius
Jan 1, 1984·Digestion·J M AllenS R Bloom
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J M LundbergB Hamberger
Oct 1, 1995·The American Journal of Physiology·C H Chen, R C Rogers
Dec 10, 1993·Regulatory Peptides·R MentleinR Krüger
Jan 1, 1994·Peptides·D GrandtJ R Reeve
May 5, 1994·Regulatory Peptides·D GrandtJ R Reeve
Mar 1, 1994·The American Journal of Physiology·E J HernandezI L Taylor
Nov 26, 1993·Neuroscience Letters·B BonazY Taché
Jul 1, 1993·Neuroscience·G BöttcherF Sundler
Feb 18, 1993·Regulatory Peptides·G BöttcherF Sundler
Jul 1, 1993·Gastroenterology·H JinW Y Chey
Dec 1, 1995·The American Journal of Physiology·T WoltmanR Reidelberger
Feb 22, 1996·Regulatory Peptides·C H ChenR L Stephens
Mar 1, 1997·Pflügers Archiv : European journal of physiology·X Fu-ChengC Rozé
Jun 1, 1997·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C H ChenR C Rogers
Jul 1, 1997·The American Journal of Physiology·C H Chen, R C Rogers
Jun 24, 1998·Biochemical and Biophysical Research Communications·M GoumainM Laburthe
Feb 10, 1999·The American Journal of Physiology·X T ZhaoH C Lin
Apr 1, 1999·Regulatory Peptides·H E RaybouldJ H Walsh
Dec 10, 1999·Regulatory Peptides·R Mentlein
Jul 18, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·D A KeireJ R Reeve
Aug 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·H YangY Taché
Feb 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R D ReidelbergerJ Permert
Jun 5, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·UNKNOWN World Medical Association General Assembly.
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T IshiguchiT Takahashi
Feb 5, 2002·Peptides·Eva Ekblad, Frank Sundler
Feb 5, 2002·Peptides·D A KeireJ R Reeve
Apr 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger D ReidelbergerDean Heimann
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·UNKNOWN World Medical Association, UNKNOWN American Physiological Society
Aug 9, 2002·Nature·Rachel L BatterhamStephen R Bloom
Oct 17, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Keishi KawakuboYvette Taché
Mar 8, 2003·Neuropharmacology·Ana P SilvaJoão O Malva
Mar 11, 2003·Experimental Biology and Medicine·Magnus M BerglundDonald R Gehlert
May 6, 2003·The Journal of Physiology·Kirsteen N Browning, R Alberto Travagli
Jun 19, 2003·British Journal of Pharmacology·Niall P HylandHelen M Cox
Citations
Jun 28, 2006·Diabetologia·S UnniappanT J Kieffer
Oct 1, 2013·Peptides·Brenna R HillNancy I Williams
Jul 14, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C N OchnerA Geliebter
Jan 14, 2011·Diabetes, Obesity & Metabolism·P P NadkarniM Sakagami
Aug 7, 2012·Diabetes, Obesity & Metabolism·T A Lutz
May 18, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jennifer L ReedNancy I Williams
Jul 5, 2012·American Journal of Physiology. Endocrinology and Metabolism·C GelegenR L Batterham
Jun 4, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Andreas StengelYvette Taché
Nov 7, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lixin WangYvette Taché
Apr 18, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Suraj Unniappan, Timothy J Kieffer
Dec 19, 2006·Critical Care : the Official Journal of the Critical Care Forum·Nam Q NguyenMichael Horowitz
May 3, 2012·Endocrine Reviews·Margaret A StefaterRandy J Seeley
Mar 29, 2014·PloS One·Yizhen WuXu-Feng Huang
Dec 24, 2011·Cellular and Molecular Life Sciences : CMLS·Thomas A Lutz
Nov 22, 2011·Acta Diabetologica·Zehra BerberogluNilgun Guvener Demirag
Apr 26, 2005·FEBS Letters·Yoram ShechterMati Fridkin
Feb 13, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Daniel P BaileyJohn Hough
Dec 10, 2008·The Journal of Physiology·Efthimia KarraRachel L Batterham
Aug 9, 2011·Nutrition·Luzia ValentiniJohann Ockenga
Jul 10, 2010·Regulatory Peptides·David A KeireJoseph R Reeve
Oct 6, 2009·General and Comparative Endocrinology·Ronald Gonzalez, Suraj Unniappan
Aug 5, 2009·Regulatory Peptides·A-B WitteP T Schmidt
Jul 1, 2009·Molecular and Cellular Endocrinology·Efthimia Karra, Rachel L Batterham
Mar 10, 2009·Physiology & Behavior·Marianne T Neary, Rachel L Batterham
Dec 18, 2015·Fish Physiology and Biochemistry·R Gonzalez, S Unniappan
May 27, 2008·Regulatory Peptides·David A KeireJoseph R Reeve
Jan 1, 2008·Neuropeptides·Dana BoeyAmanda Sainsbury
Apr 26, 2008·Clinical Endocrinology·Tasoula TsilchorozidouGerard S Conway
Mar 12, 2008·Clinical Endocrinology·Adrian VellaMichael Camilleri
Nov 23, 2006·Regulatory Peptides·P T SchmidtP M Hellström
Sep 12, 2006·Peptides·Prasanth K ChelikaniRoger D Reidelberger
May 24, 2015·European Journal of Pharmacology·Kathleen A MartinArya Mani
Sep 21, 2013·Molecular Metabolism·Keval ChandaranaRachel L Batterham
May 5, 2012·Gut Microbes·Jill A Parnell, Raylene A Reimer
Feb 24, 2015·Appetite·Daniel P BaileyCatherine J Kerr
Apr 4, 2009·International Journal of Surgery·Tayfun YucelMustafa Sit
Oct 27, 2006·Diabetes·Prasanth K ChelikaniRoger D Reidelberger
Feb 19, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Prasanth K ChelikaniRoger D Reidelberger
Oct 8, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Prasanth K ChelikaniRoger D Reidelberger
Nov 13, 2004·Endocrinology·Prasanth K ChelikaniRoger D Reidelberger
Mar 1, 2007·Expert Review of Endocrinology & Metabolism·En-Ju D LinHerbert Herzog
May 11, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ellen E Ladenheim
Jan 24, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·P JanssenJ Tack
Sep 25, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Timothy H MoranEllen E Ladenheim
Feb 23, 2020·Nutrients·Marie GalmicheMarie-Pierre Tavolacci
Mar 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mayara C F GewehrEmer S Ferro
Jan 11, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Keval Chandarana, Rachel Batterham
Jul 21, 2007·Endocrinology·K L WhitedH E Raybould
Feb 7, 2015·Endocrinology·Kelly E HenryRobert P Doyle
Jun 12, 2013·Endocrinology·Yinghua YuXu-Feng Huang