Dec 5, 2008

Comparison of the intramuscular, intranasal or sublingual routes of midazolam administration for the control of soman-induced seizures

Basic & Clinical Pharmacology & Toxicology
John H McDonoughTsung-Ming Shih

Abstract

This study evaluated the anticonvulsant effectiveness of midazolam to stop seizures elicited by the nerve agent soman when midazolam was administered by different routes (intramuscular, intranasal or sublingual) at one of two different times after the onset of seizure activity. Guinea pigs previously prepared with cortical electrodes to record brain electroencephalographic activity were pre-treated with pyridostigmine (0.026 mg/kg, intramuscularly) 30 min. before challenge with a seizure-inducing dose of the nerve agent soman (56 microg/kg, subcutaneously), and 1 min. later, they were administered 2.0 mg/kg atropine sulfate admixed with 25.0 mg/kg 2-PAM Cl (intramuscularly). Groups of animals were administered differing doses of midazolam by the intramuscular, intranasal or sublingual route at either the onset of seizure activity or 40 min. after the onset of seizure activity that was detected in the electroencephalographic record. When given immediately after seizure onset, the anticonvulsant ED50 of intramuscular midazolam was significantly lower than that of intranasal midazolam, which in turn was significantly lower than sublingual midazolam at that time. At the 40-min. treatment delay, the anticonvulsant ED50s of intramusc...Continue Reading

Mentioned in this Paper

Anticonvulsants
Cavia
Soman
Pyridostigmine
Pralidoxime
Structure of Cortex of Kidney
Non-epileptic Convulsion
Atropine Sulfate
Midazolam
Administration, Intranasal

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