Comparison of the long-term outcomes of uncinate process cancer and non-uncinate process pancreas head cancer: poor prognosis accompanied by early locoregional recurrence.

Langenbeck's Archives of Surgery
Mee Joo KangSun-Whe Kim

Abstract

The embryologic and anatomic peculiarity of the uncinate process may result in distinct clinical features, but few studies have addressed the uncinate process cancer. The purpose of this study was to compare the clinicopathologic characteristics and identify the prognostic factors that affect the survival and recurrence of pancreatic head cancer by tumor location. Between January 2002 and December 2008, 453 patients (161 with uncinate and 292 with non-uncinate process cancer) were treated for pancreatic head cancer. Clinicopathologic variables were analyzed by tumor location. Invasion into the superior mesenteric artery (SMA) occurred more frequently (p < 0.001), and overall resectability (p = 0.003), curative resection (p < 0.001), and R0 resection rates (22.3% vs 35.6%; p = 0.003) were lower for uncinate process cancer. Furthermore, overall survival after R0 resection was lower for uncinate process cancer (median 21 vs 26 months; p = 0.018), and this was accompanied by more frequent (p = 0.038) and earlier (median 13 vs 52 months; p < 0.001) locoregional recurrence. Concurrent chemoradiation increased overall (median, 26 vs 13 months; p < 0.001) and disease-free survival (median, 15 vs 6 months; p < 0.001) of uncinate and non...Continue Reading

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Citations

Jan 7, 2015·Biomedical Engineering Online·Shinuk KimTaesung Park
Feb 24, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Mee Joo KangSun-Whe Kim
Jan 19, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Woohyun JungSun-Whe Kim
Nov 14, 2014·The British Journal of Surgery·M J KangS W Kim
May 26, 2016·Journal of Computer Assisted Tomography·Ahmad Khalid OmeriHiromu Mori
Sep 26, 2017·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Yue ZhangXue-Min Chen
Jun 22, 2012·Magyar sebészet·Attila Oláh
Nov 8, 2020·Langenbeck's Archives of Surgery·Kenjiro OkadaShinya Takahashi
Feb 13, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Marit KalisvaartKeith Roberts

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