Comparison of the lubricant eyedrops Optive®, Vismed Multi®, and Cationorm® on the corneal healing process in an ex vivo model

European Journal of Ophthalmology
Ralph PinheiroRalf Michael Dutescu

Abstract

To evaluate the impact of lubricant eyedrops on the corneal healing process and corneal toxicity. Optive® and Cationorm® were tested regarding corneal irritability against Vismed Multi® and 0.01% benzalkonium chloride as negative and positive control, respectively. Formulas were applied on rabbit corneas (n = 5) cultured on artificial anterior chambers (EVEIT system) hourly over 3 days. Initially, 4 corneal abrasions (2-5.4 mm²) were induced. All defects were monitored during drug application by fluorescein stains and photographs. To ensure corneal vitality, glucose and lactate concentrations were determined photometrically in artificial anterior chamber fluids. Corneal fluorescein sodium permeability was tested as an indicator of the corneal barrier function. Optive® and Vismed Multi® showed a complete corneal healing on day 2. In one cornea (Optive®), erosion reoccurred on day 3. Erosion sizes of Cationorm®-treated corneas increased significantly from 12.20 mm² to a subtotal erosion of 51.89 mm² on day 3. Histology revealed epithelial loss and severe alterations of the superficial stroma for Cationorm®. Glucose and lactate concentrations did not change after application of Optive® and Vismed Multi®. In contrast, Cationorm®- a...Continue Reading

References

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Citations

Jun 25, 2016·BioImpacts : BI·Jaleh BararYadollah Omidi
Jul 12, 2017·Journal of Ophthalmology·Corinna FischakGerhard Garhöfer
Oct 13, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Philippe DaullJean-Sébastien Garrigue
Nov 13, 2020·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ralf M DutescuNorbert Schrage
Mar 7, 2021·Carbohydrate Polymers·Gloria Huerta Ángeles, Kristina Nešporová

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Software Mentioned

Cationorm
Optive
DISKUS
Vismed
Vismed Multi

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