PMID: 37175Jan 1, 1979

Comparison of the lytic effects of four prostaglandin analogues in the chacma baboon (Papio ursinus ursinus)

International Journal of Fertility
H J RallA Weidemann

Abstract

Six healthy, cycling female chacma baboons (Papio ursinus ursinus) were used to determine the luteolytic effects of four prostaglandin analogues. The compounds were administered according to a study design which made provision for adequate controls. Five to seven days following ovulation, venous blood was collected and the baboon given a single intramuscular injection of a compound at a recommended dose. Blood was then collected serially every 3 h for three samples and again at 24, 48, and 72 h to determine the continued effect of the prostaglandin analogues on corpus luteum production of progesterone. It was found that PGF2alpha-1,15-lactone, 11alpha(15S)-17-phenyl-18,19,20-trinor-ent-PGE2 methyl ester and 17-phenyl-18,19,20-trinor-PGF2alpha exhibited definite luteolytic potential in this species. Equivocal results were obtained with (15S)-15-methyl-PGF2Alpha THAM and its toxic qualities resulted in the demise of three animals.

Related Concepts

Venous Blood Substance
Phenyl
Progesterone, (9 beta,10 alpha)-Isomer
Portion of Venous Blood
Ovulation
Papio
Progesterone
Tromethamine
Progesterone [EPC]
Lactones

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