Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products.

Journal of Natural Medicines
Toshiaki MakinoHajime Mizukami

Abstract

According to the notification for definition of pharmaceuticals from the Director-General of the Pharmaceutical and Food Safety Bureau, Ministry of Health Labour and Welfare of Japan, the roots of Scutellaria baicalensis (Chinese skullcap) and S. lateriflora (skullcap) are classified as "the raw materials exclusively used as pharmaceuticals", but their aerial parts are classified as "non-pharmaceuticals" so, in principle, there are no health claims for these materials and no descriptions of drug-like dosages or administration directions. Dried root of S. baicalensis is also registered in Japanese Pharmacopoeia XV as scutellaria root. Scutellaria root is considered to have the adverse drug reactions of interstitial pneumonia and drug-induced hepatopathy in kampo medicines (Japanese traditional herbal formulations), and baicalin, its major constituent, is considered to be the cause of the adverse reaction. This study was conducted to evaluate the validity of this borderline between pharmaceuticals and non-pharmaceuticals by analyzing the amounts of four flavonoids, including baicalin, in the roots, stems, and leaves of S. baicalensis and S. lateriflora, and in the commercial products herbal tea and dietary supplements prepared fr...Continue Reading

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Citations

Oct 28, 2009·Journal of Medicinal Food·Sarah L MorganAngela C Kendrach
Apr 23, 2014·Chinese Journal of Integrative Medicine·Bhakta Prasad GaireHocheol Kim
Jan 13, 2010·Journal of Ethnopharmacology·Xiaofei ShangZhengping Jia
Sep 13, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Zhizhen ZhangJanet L Stringer
Aug 19, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chenghe SunShengyuan Xiao
Dec 29, 2011·American Journal of Botany·Yu-Chung ChiangPei-Chun Liao
Jun 5, 2018·Oxidative Medicine and Cellular Longevity·Roxana Braga de Andrade TelesJackson Roberto Guedes da Silva Almeida
Sep 27, 2019·Pharmacological Reviews·Dongdong WangAtanas G Atanasov
Sep 11, 2020·The American Journal of Chinese Medicine·Shuang LiDong Shang
Mar 4, 2021·International Journal of Molecular Sciences·Valentina RizzoRiccardo Ientile
Aug 28, 2021·International Journal of Molecular Sciences·Tomasz TroninaEwa Huszcza

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