Comparison of the metabolism and disposition of [3-14C]coumarin in the rat and marmoset (Callithrix jacchus)

Toxicology Letters
B G LakeS D Gangolli

Abstract

Male Sprague-Dawley rats and marmosets were given a single oral 25 mg/kg dose of [3-14C]coumarin and the excretion of radioactivity in the expired air, urine and faeces monitored up to 96 h. Excretion profiles were similar in both species with the bulk of the dose being excreted in the urine and faeces within 24 h. Chromatographic analysis of 0-48 h urine samples revealed similar metabolic profiles with only small amounts of unchanged coumarin and very little 7-hydroxycoumarin. Coumarin 7-hydroxylase activity was not detectable in hepatic microsomes from either species. These results demonstrate that the disposition of [3-14C]coumarin was similar in the rat and marmoset, a New World primate, and that both species, unlike man, are poor 7-hydroxylators of coumarin.

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Citations

Feb 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B G LakeR J Price
Feb 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B G LakeD G Walters
Jan 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J H Fentem, J R Fry
Jan 1, 1990·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C den BestenB G Lake
Mar 27, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R A FordA M Api
May 2, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B G LakeR J Price
Dec 14, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S L BornD R Hawkins
Dec 31, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H HadidiS Cholerton
Jul 27, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B G Lake
Sep 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A SteensmaB G Lake
Mar 25, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Shotaro UeharaHiroshi Yamazaki
Jun 1, 1995·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D F Lewis, B G Lake
Feb 1, 1995·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B G LakeD G Walters
Apr 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M M PetersB G Lake
Apr 11, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Shotaro UeharaHiroshi Yamazaki
Mar 17, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yao XiaoFei Li

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