Comparison of the mutation rates of human influenza A and B viruses

Journal of Virology
Eri Nobusawa, Katsuhiko Sato

Abstract

Human influenza A viruses evolve more rapidly than influenza B viruses. To clarify the cause of this difference, we have evaluated the mutation rate of the nonstructural gene as revealed by the genetic diversity observed during the growth of individual plaques in MDCK cells. Six plaques were studied, representing two strains each of type A and B viruses. A total of 813,663 nucleotides were sequenced, giving rates of 2.0 x 10(-6) and 0.6 x 10(-6) mutations per site per infectious cycle, which, when extended to 1 year, agree well with the published annual evolutionary rates.

References

May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·W M FitchP Palese
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M Kimura
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G M AirR G Webster
Apr 1, 1994·Molecular Biotechnology·P M Green, F Giannelli
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y Ina, T Gojobori
Jan 1, 1994·Analytical Biochemistry·V B Rao
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·J W Drake, J J Holland
Mar 22, 2000·The Journal of General Virology·Y HiromotoK Nerome
Nov 1, 1943·Genetics·S E Luria, M Delbrück
Nov 30, 1940·The Journal of Experimental Medicine·T Francis, A E Moore
Jan 20, 1939·The Journal of General Physiology·E L Ellis, M Delbrück

❮ Previous
Next ❯

Citations

May 28, 2008·Journal of Molecular Evolution·Rubing Chen, Edward C Holmes
Aug 14, 2012·Archives of Virology·Heidrun PlarreSiri Vike
Dec 12, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·John M NgunjiriPhilip I Marcus
Sep 16, 2011·The Journal of Infectious Diseases·Jürgen StechHans-Dieter Klenk
Mar 27, 2012·The Journal of Infectious Diseases·Alan S PerelsonFrederick G Hayden
Jul 28, 2010·Journal of Virology·Rafael SanjuánRobert Belshaw
Sep 5, 2008·Journal of Virology·Rong HaiPeter Palese
Jan 4, 2013·Journal of Virology·Christopher B BrookeJonathan W Yewdell
Oct 26, 2011·BMC Genomics·Alisa Yurovsky, Bernard M E Moret
Dec 4, 2010·PLoS Currents·Derek Gatherer
Dec 12, 2007·PLoS Computational Biology·Andreas HandelRustom Antia
Sep 25, 2010·PloS One·Martin KapunChristian Schlötterer
Apr 3, 2010·PLoS Pathogens·Rowena A BullPeter A White
Feb 15, 2013·PLoS Pathogens·Mayo YasugiKazuyoshi Ikuta
Jan 15, 2014·PLoS Pathogens·Allison L Hicks, Siobain Duffy
Dec 15, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sarah E ForgieLorne A Babiuk
Aug 24, 2013·Epidemiology and Infection·A DE DonnoM Guido
Oct 23, 2014·BMC Genomics·Saskia Metzler, Olga V Kalinina
Nov 26, 2015·Expert Review of Vaccines·Terianne M Wong, Ted M Ross
May 4, 2010·Molecular Phylogenetics and Evolution·Mathieu FourmentMark J Gibbs
Dec 9, 2009·Advances in Pediatrics·Kam-Lun Hon, Alexander K C Leung
Mar 17, 2015·Scientific Reports·Kotaro MoriKyosuke Nagata
Jan 26, 2011·Journal of Medical Virology·Karen Ka Yin WongWilliam Rawlinson
Oct 5, 2014·Vaccine·Timothy R PetersKatherine A Poehling
Dec 4, 2009·The Journal of General Virology·Edward C HutchinsonPaul Digard
Apr 16, 2013·Antiviral Research·Nick S Laursen, Ian A Wilson
Jul 6, 2010·Biochimica Et Biophysica Acta·Peleg Astrahan, Isaiah T Arkin
Mar 12, 2015·BMC Genomics·Silvie Van den HoeckeXavier Saelens
Apr 12, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Shu-Chun ChiuHsin-Fu Liu
Nov 26, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Shishir K GuptaShailendra K Gupta
Sep 10, 2013·Antiviral Research·Andrew J BurnhamElena A Govorkova

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
A J HayY P Lin
Proceedings of the National Academy of Sciences of the United States of America
J W Drake
© 2021 Meta ULC. All rights reserved