PMID: 9434849Jan 22, 1998Paper

Comparison of the mutational specificity induced by environmental genotoxin nitrated polycyclic aromatic hydrocarbons in Salmonella typhimurium his genes

Mutation Research
T WatanabeT Hirayama

Abstract

Mutagenicity of 15 nitrated polycyclic aromatic hydrocarbons (nitro PAHs), which were detected in ambient air particles and/or combustion source emissions, were examined using a set of six Salmonella typhimurium tester strains (TA7001 to TA7006), and the mutational specificity was characterized by the comparison of the mutagenic potencies of nitro-PAHs in the tester strains. Each strain carries a unique missense mutation in the histidine operon and is reverted by only one specific base-substitution out of six possible changes. All nitro-PAHs tested were mutagenic in multiple strains, and were classified into four categories based on the strains predominantly reverted. 1-Nitropyrene (1-NPy), 2,7-dinitrofluoren-9-one and 1,3-, 1,6- and 1,8-dinitropyrene isomers exerted the highest mutagenicity in strain TA7005 (C.G-->A.T transversion) followed by strain TA7006 (C.G-->G.C transversion). 2- And 3-nitrofluoren-9-one isomers, 2-NPy and 2,7-dinitrophenanthrene were also markedly mutagenic in strain TA7005 but not in strain TA7006. For 2-, 3- and 9-nitrophenanthrene isomers, 2-nitrofluoranthene (2-NFT) and 4-NPy, TA7004 (G.C-->A.T transition) was the most responsive strain. 3-NFT was unique, showing the highest mutagenicity in strain T...Continue Reading

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Citations

Nov 7, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L D ClaxtonK T Chung
Oct 6, 2007·Journal of Environmental Sciences (China)·Yun-jing LuoRu-gang Zhong
Dec 9, 2008·SAR and QSAR in Environmental Research·E Papa, P Gramatica
Jan 19, 2011·FEMS Microbiology Letters·Emiko MiyaharaToru Takeuchi
May 20, 1999·Environmental and Molecular Mutagenesis·R ZhouX Zeng

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