Comparison of the neuroendocrine control of pubertal maturation in girls and boys with spontaneous puberty and in hypogonadal girls

The Journal of Clinical Endocrinology and Metabolism
A P CemerogluR P Kelch

Abstract

Puberty in boys is characterized by a nocturnal increase in mean LH concentration and LH pulse frequency. To determine whether similar mechanisms exist in girls, nocturnal serum LH concentrations were determined in 16 girls with constitutional delay of adolescence or idiopathic short stature who had or have subsequently been shown to have spontaneous puberty. Mean LH and LH pulse frequency and amplitude were analyzed in 3-h blocks and compared to those in 20 pubertal boys. Girls had an increase in mean LH concentration from 3.6 +/- 0.7 IU/L at 2000-2250 h to 4.8 +/- 0.9 IU/L at 0200-0450 h. LH pulse frequency increased from 0.27 +/- 0.11 pulses/girl.h at 2000-2250 h to 0.54 +/- 0.10 pulses/girl.h at 0200-0450 h. The increase in LH pulse amplitude, from 2.0 +/- 0.8 IU/L at 2000-2250 h to 4.1 +/- 1.1 IU/L at 2300-0150 h, did not achieve statistical significance because many girls had no pulses from 2000-2250 h. With advancing age, the day/night differences in LH concentration and LH pulse frequency disappeared in girls, but were preserved in boys of same pubertal stage. The effect of lack of estrogen on LH pulse characteristics was inferred by analyzing the LH profiles of 15 girls with gonadal dysgenesis who were age-matched to g...Continue Reading

Citations

Nov 23, 2006·The Journal of Clinical Endocrinology and Metabolism·Christopher R McCartneyJohn C Marshall
Apr 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Yee-Ming ChanStephanie B Seminara
Oct 30, 2008·The Journal of Clinical Endocrinology and Metabolism·Christopher R McCartneyJohn C Marshall
Jan 26, 2006·Endocrine Reviews·Johannes D VeldhuisCyril Y Bowers
Jan 5, 2018·The Journal of Clinical Endocrinology and Metabolism·Su Hee KimChristopher R McCartney
Sep 28, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Heather C M AllawayMary Jane De Souza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.