Comparison of the nitric oxide and cyclo-oxygenase pathway in mesenteric resistance vessels of normotensive and spontaneously hypertensive rats

British Journal of Pharmacology
F Le Marquer-Domagala, M Finet

Abstract

1. The double perfused mesentery was used to compare arterial and venous KCl- and acetylcholine (ACh)-induced responses in tissues taken from normotensive (WKY) and spontaneously hypertensive rats (SHR) in the presence or absence of inhibitors of nitric oxide (NO) synthase (NG-nitro-L-arginine (L-NOARG) and NG-nitro-L-arginine methyl ester (L-NAME)) and cyclo-oxygenase (indomethacin, mefenamic acid). 2. KCl (20 to 120 mM K+) caused concentration-dependent increases in arterial and venous perfusion pressures. The maximal arterial effects were significantly higher in the SHRs than in the WKY, with no differences in the venous pressor responses. 3. L-NAME and L-NOARG (100 microM) had no effect on the basal perfusion pressures in tissues from either WKY or SHRs, and mefenamic acid only induced a significant reduction of the basal perfusion pressures in the venous mesenteric vessels isolated from WKY. 4. L-NAME and L-NOARG (100 microM) potentiated the pressor responses to KCl to the same extent in the venous and arterial beds derived from WKY and SHR, while indomethacin and mefenamic acid (5 microM) only significantly decreased these responses in WKY. 5. Acetylcholine (ACh)-induced relaxations (1 nM to 10 microM) were significantly ...Continue Reading

References

Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
May 1, 1990·Hypertension·T F Lüscher
Mar 1, 1988·British Journal of Pharmacology·M Feletou, P M Vanhoutte
Jul 1, 1995·British Journal of Pharmacology·M KähönenI Pörsti

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Citations

Feb 28, 2002·Journal of Cardiovascular Pharmacology·Ana M BrionesMercedes Salaices
Apr 13, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Hans H DietrichRichard W Gross
Dec 23, 2008·European Journal of Pharmacology·Amanda J Wheal, Michael D Randall
Jun 16, 2005·American Journal of Physiology. Renal Physiology·Sarah Knight, Edward J Johns
Jul 24, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Satoru Sunano, Fumiko Sekiguchi

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