Comparison of the nucleotide sequence and expression of norA genes and microbial susceptibility in 21 strains of Staphylococcus aureus

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Norihisa NoguchiMasanori Sasatsu

Abstract

The norA gene, which is located on the chromosome of Staphylococcus aureus, encodes the multidrug efflux protein with 12 transmembrane segments (TMS), and the overexpression of norA by the mutation of the transcriptional control region confers resistance to fluoroquinolones and antiseptics. In this study, the nucleotide sequence and transcriptional expression of norA genes were studied in six standard laboratory strains and 15 clinical isolates, which included 5 antiseptic-susceptible strains and 10 resistant strains. Seven mutations leading to up-regulation of norA transcription were identified. In addition, a novel allele of norA (norAII) was identified whose 3'-terminal region sequence and profile of antimicrobial susceptibility differs from those of original norA.

References

Jan 1, 1976·Antimicrobial Agents and Chemotherapy·M FinlandL D Sabath
Apr 1, 1992·Antimicrobial Agents and Chemotherapy·S B Levy
Jul 1, 1983·Antimicrobial Agents and Chemotherapy·G L Archer, J L Johnston
Jul 1, 1995·Antimicrobial Agents and Chemotherapy·J N van den AnkerP J Sauer
Sep 1, 1994·Antimicrobial Agents and Chemotherapy·H ItoS Nakamura
Nov 1, 1994·Antimicrobial Agents and Chemotherapy·H C Neu, N X Chin
May 1, 1993·Antimicrobial Agents and Chemotherapy·G W KaatzC A Ruble
Dec 1, 1995·Antimicrobial Agents and Chemotherapy·G W Kaatz, S M Seo
Dec 1, 1996·Microbiological Reviews·I T PaulsenR A Skurray
Jan 9, 1999·Clinical Microbiology Reviews·G McDonnell, A D Russell
Mar 17, 1999·Biological & Pharmaceutical Bulletin·J Katayama, N Noguchi
Apr 19, 2000·Antimicrobial Agents and Chemotherapy·G W KaatzT J Foster
Dec 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·M PutmanW N Konings

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Citations

Nov 25, 2011·Molecular Biology and Evolution·Jonathan C ThomasD Ashley Robinson
Apr 15, 2006·Clinical Microbiology Reviews·Laura J V Piddock
Aug 2, 2007·Biological & Pharmaceutical Bulletin·Hidemasa NakaminamiMasanori Sasatsu
Mar 20, 2012·Microbial Pathogenesis·Marco A Juárez-VerdayesJuan C Cancino-Diaz
Dec 24, 2008·Biochimica Et Biophysica Acta·Nir Fluman, Eitan Bibi
Apr 7, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·N Woodford
Apr 26, 2005·International Journal of Antimicrobial Agents·Norihisa NoguchiMasanori Sasatsu
May 26, 2005·The Journal of Antimicrobial Chemotherapy·Keith Poole
Jul 18, 2006·Nature Reviews. Microbiology·Laura J V Piddock
Apr 10, 2013·The Open Microbiology Journal·Sofia Santos CostaIsabel Couto
Jan 6, 2016·The Journal of Microbiology·Soojin Jang
Jan 29, 2019·Frontiers in Genetics·Sofia Santos CostaIsabel Couto

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