Dec 15, 1976

Comparison of the ototoxic effect of kanamycin on albino and pigmented rats, studied using an operant method

Experientia
E S Harpur, P F D'Arcy

Abstract

A study was made of the effect of daily administration of kanamycin (400 mg kg-1) on the hearing of Wistar albino and Lister hooded (pigmented) rats, which had been conditioned to discriminate an acoustic signal. In all animals except one, the drug caused severe, permanent hearing impairment and there was no difference between albino and pigmented rats in onset or degree. Other work has suggested a mediatory role for melanin pigment in such drug ototoxicity but the significance of this must be questioned in view of the failure to find any differences in functional deficit.

  • References9
  • Citations7

References

Mentioned in this Paper

Albinism
Discrimination Learning
Acoustic Stimulation
Kantrex
WIST, Rat Strain
Melanins
Complete Hearing Loss
Kanamycin
Metazoa
Rats, Laboratory

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