PMID: 8592800Nov 1, 1995Paper

Comparison of the pathogenicity of two US porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus

Veterinary Pathology
P G HalburJ A Rathje

Abstract

The Lelystad virus or one of two US isolates (VR2385, VR2431) of porcine reproductive and respiratory syndrome virus were given intranasally to 25 4-week-old cesarian-derived colostrum-deprived pigs. Pigs from these groups were necropsied at 1, 2, 3, 5, 7, 10, 15, 21, or 28 days postinoculation. The Lelystad virus and VR2431 induced mild transient pyrexia, dyspnea, and tachypnea. VR2385 induced labored and rapid abdominal respiration, pyrexia, lethargy, anorexia, and patchy dermal cyanosis. All three isolates induced multifocal tan-mottled consolidation involving 6.8% (n = 9; SEM = 3.4) of the lung for Lelystad, 9.7% (n = 9, SEM = 2.7) of the lung for VR2431, and 54.2% (n = 9, SEM = 4.4) of the lung for VR2385 at 10 days postinoculation. Characteristic microscopic lung lesions consisted of type 2 pneumocyte hypertrophy and hyperplasia, necrotic debris and increased mixed inflammatory cells in alveolar spaces, and alveolar septal infiltration with mononuclear cells. Lymphadenopathy with follicular hypertrophy, hyperplasia, and necrosis was consistently seen. Similar follicular lesions were also seen in Peyer's patches and tonsils. Lymphohistiocytic myocarditis and encephalitis were reproduced with all three isolates. Clinical re...Continue Reading

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Citations

Jan 5, 2014·The Journal of Microbiology·Sang-Im Yun, Young-Min Lee
Jun 5, 2003·Lancet·John M NichollsJ S Malik Peiris
May 18, 2001·Veterinary Immunology and Immunopathology·R ThanawongnuwechE L Thacker
Apr 1, 1997·Veterinary Microbiology·J J ZimmermanS L Swenson
Aug 26, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·E AlbinaB Charley
Dec 17, 2008·The Journal of Antimicrobial Chemotherapy·Angkana TantituvanontDahrit Nilubol
Aug 30, 2013·Science Translational Medicine·Surender KhuranaHana Golding
Sep 24, 2011·Clinical and Vaccine Immunology : CVI·K C O'NeillT Opriessnig
Mar 2, 2012·Journal of Virology·Lindomar PenaDaniel R Perez
Apr 12, 2012·Journal of Virology·Yao-Wei HuangXiang-Jin Meng

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