Comparison of the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) during carotid artery stenting (CAS) and carotid endarterectomy (CEA)

BMC Neurology
Ákos MéreiDiána Mühl

Abstract

Our aim was to compare the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) in during carotid endarterectomy (CEA) and carotid artery stenting (CAS). In our prospective study, twenty-five patients who were scheduled to undergo CAS were enrolled. We used a matched, historical CEA group as controls. Blood samples were collected at four time points: T1: preoperative; T2: 60 min after stent insertion; T3: first postoperative morning; and T4: third postoperative morning. Plasma MMP-9 and TIMP-1 levels were measured by ELISA. In the CEA group, the plasma levels of MMP-9 were significantly elevated at T3 compared to T1. In the CAS group, there was no significant difference in MMP-9 levels in the perioperative period. MMP-9 levels were significantly higher in the T3 samples of the CEA group compared to the CAS group. Significantly lower TIMP-1 levels were measured in both groups at T2 than at T1 in both groups. MMP-9/TIMP-1 at T3 was significantly higher than that at T1 in the CEA group compared to both T1 and the CAS group. CAS triggers smaller changes in the MMP-9-TIMP-1 system during the perioperative period, which may correlate with a lower incidence of central nervous system complications...Continue Reading

References

Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Nikolaus MarxWolfgang Koenig
Oct 3, 2003·The Journal of Biological Chemistry·Andrea HuwilerWolfgang Eberhardt
Dec 23, 2003·Journal of Neuroscience Research·Stephen J CrockerIain L Campbell
Mar 12, 2004·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·K J MolloyI M Loftus
Mar 28, 2006·Nature Medicine·Bing-Qiao ZhaoEng H Lo
Dec 1, 2006·The Journal of Biological Chemistry·Umadevi V WesleyAlbert van der Vliet
Jun 30, 2007·Journal of Vascular Surgery·Maureen M TedescoSheila M Coogan
Aug 8, 2007·Thrombosis Research·María José Santos-MartínezMarek W Radomski
Apr 16, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·C D LiapisUNKNOWN ESVS Guidelines Collaborators
Oct 6, 2009·Critical Care : the Official Journal of the Critical Care Forum·Leonardo LorenteJosé A Páramo
Nov 12, 2009·Topics in Stroke Rehabilitation·Richard D ZorowitzMarianne Laouri
Jan 30, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·John G GaudetEric J Heyer
Nov 4, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Maria Ramos-FernandezLatha G Stead
May 3, 2011·Journal of Critical Care·Diána MühlJános Lantos
Aug 2, 2011·Current Cardiology Reviews·Ernest Palomeras Soler, Virgina Casado Ruiz
Jul 31, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Leo H BonatiUNKNOWN CAVATAS Investigators
Sep 13, 2013·Molecular Neurobiology·Mayank Chaturvedi, Leszek Kaczmarek
May 3, 2014·Stroke; a Journal of Cerebral Circulation·Walter N KernanUNKNOWN American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and
Jun 10, 2014·Annals of Vascular Surgery·Enrico GiulianiAlberto Barbieri
Nov 27, 2014·Stroke; a Journal of Cerebral Circulation·Jay Chol ChoiAnthony S Kim
Nov 21, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Zohara SternbergFrederick Munschauer
Apr 12, 2016·International Journal of Cardiology·Hon-Kan YipCheuk-Man Yu
May 25, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Stephanie M MellerCarlos Mena-Hurtado
Jun 3, 2016·Neuroscience Bulletin·Jiejie Li, Yongjun Wang

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Methods Mentioned

BETA
sedation
enzyme-linked immunosorbent assay

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )

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