PMID: 823030Jan 1, 1975Paper

Comparison of the pharmacokinetics of glipizide and glibenclamide in man

European Journal of Clinical Pharmacology
L BalantG R Zahnd

Abstract

Four subjects received 5 mg 14C-glipizide orally, 3 subjects 1 mg intravenously and 2 subjects 5 mg 14C-glibenclamide orally. Plasma levels of radioactivity, and urinary and faecal excretion were measured. For both drugs the disappearance of radioactivity from plasma followed complex kinetics and the apparent half-lives increased steadily with time. The two sulfonylureas were extensively metabolized and were excreted in the urine as hydroxylated or conjugated metabolites. The effects of both drugs on blood glucose and immunoreactive insulin were comparable. The findings are compared with other published results.

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Dec 1, 1989·Journal of Clinical Pharmacology·W A KradjanF J Wood
Oct 1, 1994·Journal of Clinical Pharmacology·W A KradjanF C Wood
Jan 1, 1977·European Journal of Clinical Pharmacology·L BalantJ Fabre
Oct 1, 1980·European Journal of Clinical Pharmacology·E Wåhlin-BollB Scherstén
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Related Concepts

Blood Glucose
Neogluconin
Glupitel
Half-Life
Intravenous Injections
Novolin
Intestinal Absorption
Sulfonylurea Compounds

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