Abstract
Medical application of Panax ginseng was first found in "Shen-Nong Herbal Classic"around 200 AD Panax quinquefolium was first introduced in "Essential of Materia Medica" in 1694 in China. The most important bioactive components contained in P ginseng and P quinquefolium are ginseng saponins (GS). The contents of ginsenoside Rb1, Re, and Rd in P quinquefolium are higher than they are in P ginseng. In P ginseng, the contents of Rg1,Rb2, and Rc are higher than they are in P quinquefolium. P ginseng had a higher ratio of Rg1: Rb1, and which was lower in P quinquefolium. After steaming for several hours, the total GS will decrease. However, some ginsenosides (Rg2, 20R-Rg2, Rg3, Rh1 and Rh2) increase, while others (Rb1, Rb2, Rb3, Rc, Rd, Re, and Rg1) decrease. However, variation, especially in P quinquefolium, is high. P ginseng and P quinquefolium are general tonics and adaptogens. Rg1 and Rb1 enhance central nervous system (CNS) activities, but the effect of the latter is weaker. Thus, for the higher contents of Rg1, P ginseng is a stimulant, whereas the Rb1 contents of P quinquefolium are mainly calming to the CNS. Re, Rg1, panaxan A and B from P ginseng are good for diabetes. Re and Rg1 enhance angiogenesis, whereas Rb1, Rg3 and ...Continue Reading
References
Feb 1, 1990·Planta medica·T TakakuH Okuda
May 1, 1994·Biological & Pharmaceutical Bulletin·K SatoI Azuma
Jan 1, 1995·Life Sciences·S Y KangN D Kim
Apr 1, 1996·Japanese Journal of Cancer Research : Gann·K ShinkaiI Kitagawa
Oct 1, 1995·Diabetes Care·E A SotaniemiA Rautio
Sep 1, 1995·Biological & Pharmaceutical Bulletin·M MochizukiI Azuma
Aug 1, 1996·Clinical and Experimental Pharmacology & Physiology·X Chen
Nov 1, 1996·Biological & Pharmaceutical Bulletin·H J ParkK H Park
Jul 1, 1997·Neuroscience Research·J H LimM Sakanaka
Nov 4, 1998·The American Journal of Chinese Medicine·K H HanY W Lee
Dec 16, 1998·International Journal of Immunopharmacology·J Y RoK H Kim
Dec 23, 1998·The American Journal of Chinese Medicine·S NakajimaE Haruki
Jan 5, 1999·Experimental & Molecular Medicine·J SohnW I Hwang
Jul 6, 2000·Cancer Causes & Control : CCC·H R ShinH Vainio
Sep 22, 2000·The American Journal of Chinese Medicine·J SungB H Oh
Nov 18, 2000·Analytical Chemistry·W LiR B van Breemen
Dec 18, 2001·General Pharmacology·B H JeonK Y Nam
Dec 19, 2001·Journal of Korean Medical Science·T K YunH Y Yun
May 29, 2002·Diabetes·Anoja S AtteleChun-Su Yuan
Jun 6, 2002·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·J T XieC S Yuan
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Robbie Y K ChanMan-Sau Wong
Sep 18, 2002·Archives of Biochemistry and Biophysics·David G Popovich, David D Kitts
Mar 12, 2003·Mutation Research·Young-Sam KeumYoung-Joon Surh
Apr 5, 2003·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhengxiang LiuXiaochun Liu
May 7, 2003·The Journal of Steroid Biochemistry and Molecular Biology·YoungJoo LeeSeungKi Lee
Aug 12, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Alexa T Smolinski, James J Pestka
Sep 19, 2003·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L DeyC S Yuan
Oct 10, 2003·British Journal of Pharmacology·Nak Doo KimSang Geon Kim
Dec 4, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jing-Tian XieChun-Su Yuan
Jan 7, 2004·Journal of Agricultural and Food Chemistry·Valerie A AssineweJ Thor Arnason
Jan 31, 2004·Phytochemistry·David G Popovich, David D Kitts
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Jungyoon ChoYoungjoo Lee
Sep 1, 2004·Circulation·Shiladitya SenguptaTai-Ping D Fan
Jan 13, 2005·Neuroscience Letters·Jingwei TianKe Liu
Apr 2, 2005·Biological & Pharmaceutical Bulletin·Eun-Kyung ParkDong-Hyun Kim
Apr 23, 2005·Pharmaceutical Research·Ya-Chun HuangHsing-Wen Sung
Jun 14, 2005·Biochimica Et Biophysica Acta·Jing-Tian XieChun-Su Yuan
Jul 29, 2005·The American Journal of Chinese Medicine·Jing-Tian XieChun-Su Yuan
Oct 6, 2005·Biological & Pharmaceutical Bulletin·Eun-Ah BaeDong-Hyun Kim
Jan 27, 2006·The American Journal of Chinese Medicine·Hye Hyun YooHyun Young Kim
Mar 7, 2006·Journal of Pharmacological Sciences·Khaled RadadWolf-Dieter Rausch
Jun 27, 2006·Journal of Ethnopharmacology·William C S ChoKevin K M Yue
Jul 15, 2006·Phytochemistry·Erin M Schlag, Marla S McIntosh
Oct 10, 2006·European Journal of Pharmacology·William C S ChoKevin K M Yue
Jan 2, 2007·Biochemical and Biophysical Research Communications·Jing YuTetsuro Okabe
Feb 6, 2007·International Immunopharmacology·Chun Fu WuXian Li
May 16, 2007·Chinese Medicine·Patrick Ying Kit YueRicky Ngok Shun Wong
Jun 1, 2007·Planta medica·Chong-Zhi WangChun-Su Yuan
Jul 28, 2007·Life Sciences·Kai SunJing-Yan Han
Sep 20, 2007·The Journal of Medical Investigation : JMI·Yutaka NakayaSonoko Yasui
Citations
Mar 7, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Gengyao HuGang Zhao
Oct 4, 2011·Angiogenesis·Kar-Wah LeungAlice S T Wong
Jul 10, 2012·Chinese Journal of Integrative Medicine·Si-Dao ZhengDe-Lin Wu
May 15, 2013·Computers in Biology and Medicine·Natarajan SathishkumarDeok-Chun Yang
Dec 3, 2013·Journal of Agricultural and Food Chemistry·Lijun WangGuixing Ren
Sep 17, 2010·Journal of Sports Sciences·Chanchira WasuntarawatGlenn McConell
Sep 22, 2010·Cardiovascular Research·Lydia W T CheungAlice S T Wong
Oct 25, 2011·Applied and Environmental Microbiology·Eun-Mi KimByung-Gee Kim
Apr 27, 2010·BMC Genomics·Chao SunShilin Chen
Apr 13, 2013·BMC Genomics·Chunfang LiShilin Chen
Aug 21, 2013·BMC Genomics·Di WuDan Brown
May 23, 2012·Journal of the International Society of Sports Nutrition·Szu-Hsien YuChia-Hua Kuo
May 20, 2011·Chinese Medicine·Xiao-Fan LiYung Kin-Lam Ken
Apr 3, 2012·Biological & Pharmaceutical Bulletin·Il-Hoon JungDong-Hyun Kim
Oct 12, 2011·Drugs·Morris KarmazynXiaohong Tracey Gan
May 3, 2014·Biological & Pharmaceutical Bulletin·Heon-Sub ShinTae-Hoo Yi
Jun 5, 2013·Cell Biochemistry and Biophysics·Ning LinJiao-Jiao Shi
May 29, 2014·Journal of Pharmaceutical and Biomedical Analysis·Qian MaoSong-Lin Li
Aug 13, 2013·Gene·Xiaochen ChenShilin Chen
May 8, 2014·Nutrients·Hyejung HwangKiwon Lim
Oct 15, 2013·Canadian Journal of Physiology and Pharmacology·Misagh AlipourZacharias E Suntres
Aug 21, 2012·Neurochemical Research·Nazmun LyleDipankar Bhattacharyya
Sep 24, 2015·International Journal of Food Sciences and Nutrition·Yim Tong SzetoWouter Kalle
Feb 3, 2015·International Journal of Molecular Sciences·Hongzhe CaoZhiyong Luo
Oct 18, 2016·Journal of Ginseng Research·Jong-Hak KimDeok-Chun Yang
Dec 6, 2014·Journal of the Chinese Medical Association : JCMA·Yanping DengBaohong Jiang
Feb 4, 2016·International Journal of Molecular Sciences·Song-Di WuMing Shi
Aug 14, 2015·Journal of Chromatographic Science·Wei WuShuying Liu
Apr 18, 2013·Phytochemistry·Erin M Schlag, Marla S McIntosh
May 30, 2013·Journal of Ginseng Research·Ik-Hyun Cho
May 30, 2013·Journal of Ginseng Research·Ho Jae ParkJong Hoon Ryu
May 23, 2012·Journal of Bioscience and Bioengineering·Fang YangZunxi Huang
Apr 19, 2011·Journal of Pharmaceutical and Biomedical Analysis·Hongtao WangDeok-Chun Yang
Mar 15, 2011·Phytochemistry·Lian-Wen QiChun-Su Yuan
Jul 16, 2010·Fitoterapia·Rui LiuYiNan Zheng
Dec 9, 2015·Journal of Chromatography. a·Yaping WangLinfang Huang
Oct 20, 2015·The American Journal of Chinese Medicine·Pengcheng WangHaixue Kuang
Mar 16, 2016·Journal of Ethnopharmacology·Sha ChenAn Liu
Jun 10, 2015·Scientific Reports·Eun-Mi KimByung-Gee Kim
Jun 8, 2011·Journal of Clinical Pharmacology·Christine Y MalatiScott R Penzak
Jun 28, 2011·Geriatrics & Gerontology International·Shun ShiKiyoshi Hashizume
Apr 5, 2012·Phytotherapy Research : PTR·Florian HerrmannMichael Wink
Apr 16, 2011·The Journal of Pharmacy and Pharmacology·Ramses IlarrazaDarryl J Adamko
Dec 2, 2009·Physiologia Plantarum·Qiong WuChao Sun
Mar 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Betty Yuen Kwan LawVincent Kam Wai Wong
Apr 12, 2016·Frontiers in Plant Science·Wei SunShi-Lin Chen
Jun 25, 2015·Luminescence : the Journal of Biological and Chemical Luminescence·Jingxiang PangJinxiang Han
Jun 12, 2012·Journal of Ethnopharmacology·Tian LinGang Zhao
Jul 23, 2015·Journal of Ginseng Research·Jyoti Sharma, Pradeep K Goyal
Feb 7, 2015·Chinese Medicine·Yat-Tung LoPang-Chui Shaw