Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung

Antioxidants
Masanori HorieYasuo Morimoto

Abstract

NiO nanoparticles were administered to rat lungs via intratracheal instillation or inhalation. During pulmonary toxicity caused by NiO nanoparticles, the induction of oxidative stress is a major factor. Both intratracheal instillation and inhalation of NiO nanoparticles induced pulmonary oxidative stress. The oxidative stress response protein, heme oxygenase-1 (HO-1), was induced by the administration of NiO nanoparticles at both the protein and gene expression level. Additionally, certain oxidative-stress markers in the lung, such as 8-iso-prostaglandin F2α, thioredoxin, and inducible nitric oxide synthase were increased. Furthermore, the concentration of myeloperoxidase (MPO) in the lung was also increased by the administration of NiO nanoparticles. When the amount of NiO in the lung is similar, the responses against pulmonary oxidative stress of intratracheal instillation and inhalation are also similar. However, the state of pulmonary oxidative stress in the early phase was different between intratracheal instillation and inhalation, even if the amount of NiO in the lung was similar. Inhalation causes milder oxidative stress than that caused by intratracheal instillation. On evaluation of the nanoparticle-induced pulmonary ...Continue Reading

References

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May 23, 2014·Cellular Microbiology·William M Nauseef

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Citations

Feb 10, 2018·Applied Microbiology and Biotechnology·Cátia A SousaEduardo V Soares
Jun 13, 2018·Journal of Clinical Biochemistry and Nutrition·Yun-Shan LiKazuaki Kawai
Apr 13, 2021·Ecotoxicology and Environmental Safety·Rehab HegazyDalia Saleh
Jul 26, 2018·Chemical Research in Toxicology·Cátia A SousaEduardo V Soares
Jun 1, 2019·Biochimica Et Biophysica Acta. Biomembranes·Daniele ZanellaGiovanni Bernardini

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Methods Mentioned

BETA
lavage
protein assay
enzyme-linked immunosorbent assay
bronchoalveolar
ELISA
PCR

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