PMID: 6169071Jan 1, 1980Paper

Comparison of the R-3327H rat prostatic adenocarcinoma to human benign prostatic hyperplasia and metastatic carcinoma of the prostate with regard to steroid hormone receptors

The Prostate
E DahlbergJ A Gustafsson

Abstract

Quantitative analyses of cytosolic steroid hormone receptors were performed on nine tumors from the transplantable rat prostatic adenocarcinoma R-3327H. Androgen receptors and estrogen receptors were found in eight of nine and five of six tumors, respectively. None of the tumours analyzed contained detectable progestin or glucocorticoid receptors (four and seven tumors, respectively). The apparent equilibrium dissociation constants for the androgen and estrogen receptors were 0.7-4.3 nM and 0.6-1.8 nM, respectively. The apparent equilibrium Bmax values (maximum number of binding sites) were 1,500-25,000 fmoles/gm tissue for the androgen receptor and 640 to 5,800 fmoles/gm tissue for the estrogen receptor. A comparison between the receptor contents of the R-3327H rat tumor and human benign prostatic hyperplasia and metastatic carcinoma of the prostate showed that the rat tumor was different from the human tissues in several respects. Hence, the search for an optimal animal model for prostatic carcinoma in man must be continued.

References

Aug 1, 1979·The Journal of Clinical Endocrinology and Metabolism·P EkmanJ A Gustafsson
Oct 1, 1975·Steroids·G C Chamness, W L McGuire
Apr 1, 1978·Metabolism: Clinical and Experimental·W L McGuireG C Chamness
Feb 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P EkmanJ A Gustafsson
Jul 1, 1977·The Journal of Urology·J K SmolevW W Scott
Jan 1, 1977·Oncology·H Handelsman
Mar 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·J D Baxter, G M Tomkins
Jul 1, 1973·Steroids·D Philibert, J P Raynaud
Dec 1, 1971·Steroids·J P RaynaudE E Baulieu
Jan 1, 1980·Acta Chemica Scandinavica. Series B: Organic Chemistry and Biochemistry·E DahlbergJ A Gustafsson

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Citations

Jun 30, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·T SmithF K Habib
Jan 1, 1980·Journal of Steroid Biochemistry·J P RaynaudJ P Mornon
Aug 1, 1981·Journal of Steroid Biochemistry·M SnochowskiJ A Gustafsson
May 1, 1983·Journal of Steroid Biochemistry·T SmithF K Habib
Jan 1, 1982·The Prostate·M S GesellD Brandes

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