PMID: 8467356Mar 1, 1993Paper

Comparison of the regional haemodynamic effects of the AT1-receptor antagonists, losartan and EXP 3174, in water-deprived Brattleboro rats

British Journal of Pharmacology
R E WiddopT Bennett

Abstract

1. Two separate groups (n = 8) of Brattleboro rats, chronically instrumented for the measurement of regional haemodynamics, underwent a 2-stage experimental protocol. Initially, animals had their drinking water removed and cardiovascular recordings were made every 30 min for the following 6 h. Then animals received either the AT1-receptor antagonist, losartan (3 mg kg-1, i.v., n = 8), or an initially equi-hypotensive dose of its active metabolite, EXP 3174 (1 mg kg-1, i.v., n = 8), and the resultant cardiovascular changes were monitored for a further 2 h. A third group of Brattleboro rats (n = 8) was water-deprived for 8 h to serve as a time control. 2. In all 3 groups of animals, mesenteric and hindquarters vasoconstriction (beginning approximately 30 and 120 min, respectively, after water was removed) occurred much earlier than changes in blood pressure, since increases in blood pressure were significant only after 5-6 h of water deprivation; renal perfusion was largely unchanged. The observation of a differential onset of haemodynamic changes (i.e. mesenteric > hindquarters > renal) extends our previous findings, in which measurements were made only at the end of a 14 h period of water-deprivation. 3. When given after 6 h of...Continue Reading

References

May 14, 1992·European Journal of Pharmacology·K MizunoS Fukuchi
Sep 1, 1992·Trends in Pharmacological Sciences·U M SteckelingsT Unger
Sep 24, 1991·European Journal of Pharmacology·P C WongP B Timmermans
Dec 1, 1991·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·L A SechiM Schambelan
Feb 1, 1991·Trends in Pharmacological Sciences·P B TimmermansW F Herblin

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Citations

Apr 15, 2015·Physiology & Behavior·Natalie C HeyseRainer K W Schwarting
Dec 18, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joanne J CarterJeanette Woolard

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