PMID: 6167377Jan 1, 1981Paper

Comparison of the response of synchronized HeLa cells to talisomycin and bleomycin

Cancer Chemotherapy and Pharmacology
C K Mirabelli, S T Crooke

Abstract

The cytotoxic activities of the antitumor antibiotics talisomycin (TLM) and bleomycin (BLM), were compared with asynchronous and synchronous populations of HeLa cells. The sensitivities of asynchronous and synchronous cells to TLM and BLM were expressed as biphasic dose-response survival curves. Of the cell cycle populations investigated, mitotic phase cells were the most sensitive and G1 phase cells the most resistant to tLM and BLM cytotoxic activity. A significantly greater portion of mid-G1 cells was more resistant to TLM than to BLM. Mid-S-phase cells showed greater resistance to TLM than to BLM in the initial portion (primary slope) of the dose-response curve.

References

Oct 1, 1977·Nucleic Acids Research·L F PovirkF Hutchinson
May 16, 1978·Biochemistry·R S LloydD L Robberson
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R S LloydD L Robberson
Dec 14, 1979·Biochemical and Biophysical Research Communications·C MirabelliS T Crooke
Jan 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B DrewinkoB Barlogie
Dec 18, 1972·European Journal of Biochemistry·W E MüllerR K Zahn
Feb 1, 1974·British Journal of Cancer·D N WheatleyK Kajiwara
Jun 1, 1970·The Journal of Antibiotics·T Terasima, H Umezawa

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