Comparison of the simple cyclic voltammetry (CV) and DPPH assays for the determination of antioxidant capacity of active principles.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jesús F ArteagaJosé M Rodríguez-Mellado

Abstract

Antioxidant activity of a number of small (low molecular weight) natural compounds found in spices, condiments or drugs (gallic acid, sesamol, eugenol, thymol, carvacrol, vanillin, salicylaldehyde, limonene, geraniol, 4-hexylresorcinol, etc.) has been evaluated using electrochemical and DPPH• radical scavenging measurements. Structural analysis of the tested compound suggest a remarkable activity for phenol derivatives and the importance of the -R groups located on the phenolic ring in the molecule's ability to act as free radical scavenging as well as their influence in the electrochemical behavior. The voltammetric method can be used for the determination of the antioxidant capability in the same manner as the DPPH• radical scavenging because of the correlation found between oxidation potentials and anti-radical power (ARP = 1/EC₅₀). Such electrochemical determination is fast and cheap and allows making measurements under a variety of experimental conditions. The accuracy of the electrochemical measurements is the same for all the compounds, irrespective of their scavenging activity, the opposite of what occurs in the DPPH• test.

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Citations

Jun 5, 2013·Asian Pacific Journal of Tropical Biomedicine·Repon Kumer SahaaPriyanka Royb
Sep 30, 2014·Journal of Agricultural and Food Chemistry·Alberto PalmaJose M Rodríguez Mellado
Mar 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martina MiceliTecla Gasperi
Jul 1, 2017·Arhiv za higijenu rada i toksikologiju·Ivana Novak Jovanović, Ante Miličević
Jan 31, 2018·Current Microbiology·Ramasamy MahendranJayaraman Angayarkanni
Jul 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zdenka BedlovičováAneta Salayová
Aug 14, 2019·Antioxidants·Khiena BraininaMarina Vidrevich
Jan 4, 2017·Oxidative Medicine and Cellular Longevity·Aurelia Magdalena PisoschiGabriel Predoi
Jan 28, 2019·Plant Foods for Human Nutrition·Kristina GopčevićZoran Maksimović
Jan 26, 2021·Journal of Analytical Methods in Chemistry·Georgii S VasylievOlga V Linyucheva
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Ana-Maria Chiorcea-PaquimAna Maria Oliveira-Brett

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