Comparison of the Simplified sWHI and the Standard CHS Frailty Phenotypes for Prediction of Mortality, Incident Falls, and Hip Fractures in Older Women

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Oleg ZaslavskyNancy Fugate Woods

Abstract

We compared the simplified Women's Health Initiative (sWHI) and the standard Cardiovascular Health Study (CHS) frailty phenotypes in predicting falls, hip fracture, and death in older women. Participants are from the WHI Clinical Trial. CHS frailty criteria included weight loss, exhaustion, weakness, slowness, and low physical activity. The sWHI frailty score used two items from the RAND-36 physical function and vitality subscales, one item from the WHI physical activity scale plus the CHS weight loss criteria. Specifically, level of physical function was the capacity to walk one block and scored as severe (2-points), moderate (1-point), or no limitation (0). Vitality was based on feeling tired most or all of the time (1-point) versus less often (0). Low physical activity was walking outside less than twice a week (1-point) versus more often (0). A total score of 3 resulted in a frailty classification, a score of 1 or 2 defined pre-frailty, and 0 indicated nonfrailty. Outcomes were modeled using Cox regression and Harrell C-statistics were used for comparisons. Approximately 5% of the participants were frail based on the CHS or sWHI phenotype. The sWHI frailty phenotype was associated with higher rates of mortality (hazard rati...Continue Reading

References

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Jun 17, 2016·Journal of the American Geriatrics Society·Oleg ZaslavskyNancy F Woods

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Citations

Apr 17, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Timo E StrandbergHannu Kautiainen
Nov 23, 2019·Journal of Gerontological Nursing·Andrew K TengAnnie T Chen
Aug 18, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Oleg ZaslavskyEric B Larson
Feb 7, 2021·Ageing Research Reviews·V KnoopUNKNOWN Gerontopole Brussels Study group
Apr 30, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Oleg ZaslavskyEric B Larson

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