Comparison of the single simple question and the patient acceptable symptom state in myasthenia gravis.

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Deepak MenonVera Bril

Abstract

The single simple question (SSQ) is a simple and validated question asking what percentage of normal a patient feels with respect to their myasthenia gravis (MG), with 100% being normal. Patient acceptable symptom states (PASS) are based on a dichotomous 'Yes' or 'No' response, asking whether a patient is satisfied overall with their current status and thus measures holistic satisfaction with their MG state. Both are patient-reported self-assessments but assess different dimensions of MG. The objective was to determine thresholds for the SSQ when patients with MG achieve an acceptable PASS status. A retrospective chart review was performed of consecutive MG patients attending a neuromuscular clinic, and SSQ and PASS responses, demographic, clinical and serological characteristics and disease severity by the MG impairment index were extracted. One hundred and fifty-seven consecutive patients were identified: 43 (27.4%) patients responded 'No' to the PASS question. Between the PASS 'Yes'/'No' groups, only SSQ (87.5 ± 13.4 vs. 52.3 ± 23.3; P < 0.001) and MG impairment index scores (9.2 ± 10.3 vs. 29.6 ± 16; P < 0.001) were significantly different. The receiver operating characteristic curve for PASS and SSQ had an area under the c...Continue Reading

References

Jan 3, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ghizlane WariaghliNajia Hajjaj-Hassouni
Dec 14, 2016·The New England Journal of Medicine·Gil I WolfeGary R Cutter
Apr 16, 2018·Neurologic Clinics·Carolina BarnettRichard J Barohn

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Citations

Aug 12, 2021·Neurology·Chloe Atkins, Carolina Barnett
Oct 13, 2021·Neuromuscular Disorders : NMD·Nils Erik GilhusJacqueline Palace

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