Comparison of the synaptosomal uptake inhibition of serotonin by St John's wort products

The Journal of Pharmacy and Pharmacology
S Schulte-LöbbertM Wurglics

Abstract

Although the number of prescriptions for psychotropic drugs has decreased in recent years, prescriptions for antidepressants are still increasing (Fritze 2002). Hypericum perforatum (St John's wort) is the main psychotherapeutic herbal medicinal product used for treatment of mild-to-moderate depression. The lipophilic constituent hyperforin (2-5% of the extract) demonstrated, similarly to chemical antidepressants, a significant effect on the synaptosomal uptake inhibition of several neurotransmitters in in-vitro assays. In Germany, St John's wort products are distributed via two different markets: products that are pharmacy restricted are only allowed to be distributed in pharmacies; traditionally used products, which do not claim to have a curative character, are allowed to be sold in supermarkets. Depending on the market wherein a St John's wort product is offered, it needs to fulfill the legal requirements regarding pharmaceutical quality, safety and efficacy. Our goal was to compare the quality of St John's wort products distributed in pharmacies with that of those available from supermarkets. Therefore, the quantity of the pharmaceutical active ingredients (the phloroglucinol derivate hyperforin, the flavonoids rutin, hype...Continue Reading

References

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Aug 30, 2003·Journal of Pharmaceutical and Biomedical Analysis·S Schulte-LöbbertM Wurglics

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Citations

Jun 9, 2011·Molecular Cancer·Maurice Israël, Laurent Schwartz
Apr 28, 2006·Clinical Pharmacokinetics·Mario Wurglics, Manfred Schubert-Zsilavecz
Oct 18, 2005·The Medical Clinics of North America·Christopher P HolstegeR Brent Furbee
Jan 26, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Alexander PaulkeMario Wurglics
Oct 10, 2006·Journal of Clinical Epidemiology·Joel J GagnierUNKNOWN CONSORT Group
Dec 3, 2016·International Clinical Psychopharmacology·Siu Wa TangBrian E Leonard
Oct 12, 2017·Psychopharmacology·Carmen ConcertoFortunato Battaglia
Apr 15, 2010·Annals of the New York Academy of Sciences·M Eric GershwinM R C Greenwood
Jun 3, 2018·European Journal of Drug Metabolism and Pharmacokinetics·Lilian W KibathiParag Kumar

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