PMID: 9004907Jan 1, 1996Paper

Comparison of the targeting characteristics of various radioimmunoconjugates for radioimmunotherapy of neuroblastoma: dosimetry calculations incorporating cross-organ beta doses

Nuclear Medicine and Biology
O UgurS M Larson

Abstract

To optimize the efficacy of radioimmunotherapy (RIT), the ideal antibody-radioisotope combinations should be used to deliver the highest tumor and the lowest normal tissue doses. In a mouse model, tumor and critical organ-absorbed doses delivered by different radioimmunoconjugates were calculated and compared. We used a Medical Internal Radiation Dosimetry (MIRD)-style mouse dosimetry model that incorporates cross-organ beta doses to make refined estimates of the radiation absorbed dose to tissues. Biodistribution data from neuroblastoma xenografted nude mice were used to estimate tumor, organ and bone marrow absorbed dose values for 90Y-3F8, 131I-3F8 and 131I-F(ab')2 fragments. Immunoreactive fractions of the radiolabeled antibodies were comparable. Although tumor uptake of the radioiodinated and radiometal labeled 3F8 was much higher than that of the radioiodinated F(ab')2 fragments (maximum percent injected dose per gram values were 39.4, 33.2 and 20.1 for 131I-3F8, 90Y-3F8 and 131I-F(ab')2, respectively), tumor to nontumor ratios were higher for radioiodinated fragments (with the exception of tumor to kidney ratio). For the minimum tumor dose necessary for complete ablation, the bone marrow received 195, 278 and 401 cGy for...Continue Reading

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Citations

Jun 1, 1997·Cancer Biotherapy & Radiopharmaceuticals·A VoigtF Zintl
Apr 11, 2014·International Journal of Endocrinology and Metabolism·Evangelia Skoura
Oct 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Stephan D VossAlan B Packard
Jul 18, 2000·International Journal of Cancer. Journal International Du Cancer·M RutgersL A Smets
Jun 25, 1999·Acta Oncologica·J S LampinenS E Savolainen
Feb 24, 2001·Cancer Biotherapy & Radiopharmaceuticals·C S CutlerE Deutsch
Apr 18, 2003·Cancer Immunology, Immunotherapy : CII·Paul ChinnNabil Hanna
Dec 26, 2001·Chemical Reviews·W A Volkert, T J Hoffman

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