PMID: 6113174Jan 1, 1981Paper

Comparison of the therapeutic effect, tolerance and safety of ketazolam and diazepam administered for six months to out-patients with chronic anxiety neurosis

The Journal of International Medical Research
L F FabreA G Stephens

Abstract

Recently, it has been argued that benzodiazepines may not be safe or efficacious beyond 3 months continuous dosage. This study was designed to provide data regarding efficacy, safety, possible tolerance development, and possible withdrawal effects of administering ketazolam and diazepam for a 6-month period. Chronic anxiety patients were screened for participation according to specific inclusion and exclusion criteria. Of 139 patients, forty-four terminated prematurely for non-drug related reasons and are not included in the analysis. Of the ninety-five patients remaining, sixty-three were on ketazolam, and thirty-two on diazepam. Efficacy parameters included the Hamilton Anxiety Rating Scale, Physician's Global Impressions, Target Symptoms, Self-Rating Symptom Scale, and Patient's Global Impressions. Patients were evaluated weekly for the first month except for Week 3, and then seen bi-weekly and rated monthly. The results of the study showed that ketazolam was as efficacious as diazepam in treating anxiety and resulted in fewer side-effects. No adverse effects were noted in either group. Both benzodiazepines were safe and well-tolerated. No tolerance or withdrawal effects were noted. The average doses were ketazolam Week 4 (5...Continue Reading

References

Jan 1, 1976·The Journal of International Medical Research·L F Fabre, R T Harris
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Citations

May 1, 1994·Pain·P L Dellemijn, H L Fields
Jun 4, 2019·The Cochrane Database of Systematic Reviews·Yusuke OgawaToshi A Furukawa
Jul 6, 2019·International Clinical Psychopharmacology·Masaki ShinfukuToshiaki Kikuchi
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Jan 1, 1988·Psychological Medicine. Monograph Supplement·A HiggittM Lader
Dec 16, 1997·The Medical Journal of Australia·T R NormanG D Burrows

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