Comparison of the treatment outcomes of intensity-modulated radiotherapy and two-dimensional conventional radiotherapy in nasopharyngeal carcinoma patients with parapharyngeal space extension

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Ling-Long TangJun Ma

Abstract

This study investigated the contribution of intensity-modulated radiotherapy (IMRT) to improved treatment outcome in patients with nasopharyngeal carcinoma (NPC) and parapharyngeal space (PPS) extension. A total of 1052 cases with PPS extension were retrospectively reviewed, including 512 (48.7%) patients treated with two-dimensional conventional radiotherapy (2D-CRT) and 540 (51.3%) patients treated with IMRT. Significant differences in local relapse-free survival (LRFS) and overall survival (OS) (P<0.001, P<0.001, respectively), but not distant metastasis-free survival (DMFS; P=0.383), were observed between the 2D-CRT and IMRT groups in univariate analysis. The radiotherapy technique was found to be an independent prognostic factor for death (HR=0.674, 95% CI: 0.537-0.846, P=0.001) and local recurrence (HR=0.486, 95% CI: 0.324-0.727, P<0.001), but not for DMFS. IMRT improved local control in patients with carotid space (CS) involvement compared to 2D-CRT (P<0.001). LRFS was significantly different between patients with and without CS extension in the 2D-CRT group (P<0.001), but not in the IMRT group (P=0.215). Compared to 2D-CRT, IMRT improved LRFS in patients with PPS extension, especially patients with CS extension, but did...Continue Reading

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Citations

Sep 24, 2020·International Journal of Technology Assessment in Health Care·Akashdeep Singh ChauhanRoshan Verma

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