Comparison of the vaginal environment of Macaca mulatta and Macaca nemestrina throughout the menstrual cycle

American Journal of Reproductive Immunology : AJRI
Sarah V HadzicRonald S Veazey

Abstract

Pigtail macaques, Macaca nemestrina (PT), are more susceptible to vaginal transmission of simian immunodeficiency virus (SIV) and other sexually transmitted diseases (STD) than rhesus macaques (RM). However, comparative studies to explore the reasons for these differences are lacking. Here, we compared differences in hormone levels and vaginal mucosal anatomy and thickness of RM and PT through different stages of the menstrual cycle. Concentrations of plasma estradiol (E2) and progesterone (P4) were determined weekly, and vaginal biopsies examined at days 0 and 14 of the menstrual cycle. Consistent changes in vaginal epithelial thickness occurred at different stages of the menstrual cycle. In both species, the vaginal epithelium was significantly thicker in the follicular than in luteal phase. Keratinized epithelium was strikingly much more prominent in RM, especially during the luteal phase. Further, the vaginal epithelium was significantly thinner, and the P4:E2 ratio was higher in PT during luteal phase than RM. Striking anatomic differences in the vaginal epithelium between rhesus and pigtail macaques combined with differences in P4:E2 ratio support the hypothesis that thinning and less keratinization of the vaginal epithel...Continue Reading

References

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Citations

Sep 10, 2014·Viruses·Iskra Tuero, Marjorie Robert-Guroff
Aug 21, 2015·American Journal of Reproductive Immunology : AJRI·Whitney A NicholsAngela M Amedee
Dec 24, 2014·Journal of Medical Primatology·Sharon Dietz OstergaardEllen Kersh
Apr 11, 2014·American Journal of Reproductive Immunology : AJRI·Janet McNichollEllen Kersh
Aug 5, 2015·Journal of Medical Primatology·Katherine ButlerEllen Kersh
Aug 9, 2015·BMC Veterinary Research·Dillon C MuthKenneth W Witwer
Nov 22, 2014·The Journal of Infectious Diseases·Thomas R Moench
Nov 7, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Iskra TueroMarjorie Robert-Guroff
Jun 17, 2020·Biology of Reproduction·Nirk E Quispe CallaThomas L Cherpes
Jul 9, 2016·Clinical Science·Morgane GriesbeckMarcus Altfeld
Feb 13, 2021·Tissue Engineering. Part C, Methods·Ingrid SabaStéphane Bolduc

Related Concepts

Disease Susceptibility
Estradiol, (16 alpha,17 beta)-Isomer
Menstrual Cycle, Proliferative Phase
Luteal Phase
Macaca mulatta
Macaca nemestrina
Muscularis Mucosae
Progesterone, (9 beta,10 alpha)-Isomer
Vagina
Simian immunodeficiency virus

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