PMID: 8608189Oct 1, 1995Paper

Comparison of the values of basic fibroblast growth factor determined by an immunoassay in the sera of patients with traumatic brain injury and enhanced osteogenesis and the effects of the same sera on the fibroblast growth in vitro

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
Renate WildburgerM Trbojević-Cepe

Abstract

In patients with severe traumatic brain injury, the early healing of fractures is accompanied by hypertrophic callus formation or heterotopic ossifications, which might even result in ankylosis of the affected joints. Analysis of the sera of patients with traumatic brain injury revealed post-traumatic dynamic changes of basic fibroblast growth factor immunoreactivity, similar to those observed during fracture healing associated with enhanced osteogenesis. The aim of this study was to determine whether such changes in basic fibroblast growth factor concentrations could be related to the phenomenon of enhanced osteogenesis. Basic fibroblast growth factor immunoreactivity was determined (using an IEMA kit) in the sera of patients with traumatic brain injury and bone fractures (n = 8) and in the sera of patients with either traumatic brain injury alone (n = 10) or bone fractures alone (n = 7), and the effects of these sera on L929 fibroblast growth were analysed in vitro. The results did not prove a causative relationship between the changes of basic fibroblast growth factor immunoreactivity and in vitro growth promoting effects of the sera. However, it is apparent that, in addition to changes in the growth-promoting activity and b...Continue Reading

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Citations

May 19, 1998·Journal of Endocrinological Investigation·R WildburgerK Zarkovic
Nov 19, 2013·Journal of Biomedical Materials Research. Part a·Lidija MilkovicNeven Zarkovic
Feb 16, 2005·Injury·John MorleyPeter V Giannoudis
Sep 5, 2006·Biochemical and Biophysical Research Communications·Lin LinChanglong Yu
Oct 3, 2006·The Journal of Bone and Joint Surgery. British Volume·K EidM Keel
Dec 2, 2008·The Journal of Bone and Joint Surgery. British Volume·T W AxelradT A Einhorn

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