Comparison of the Variability of SUV Normalized by Skeletal Volume with the Variability of SUV Normalized by Body Weight in 18 F-Fluoride PET/CT

Journal of Nuclear Medicine Technology
José Flávio Gomes MarinCarlos Alberto Buchpiguel

Abstract

Our objective was to test the hypothesis that variability in SUV normalized by skeletal volume (SV) in 18F-fluoride (18F-NaF) PET/CT studies is lower than variability in SUV normalized by body weight (BW). Methods: The mean SUV (SUVmean) was obtained for whole skeletal volume of interest (wsVOI) in 163 selected 18F-NaF PET/CT studies. These studies were performed to investigate bone metastases and were considered to have normal results. SUVmean was calculated with normalization by BW (BW SUVmean), with normalization by SV (SV SUVmean), and without normalization (WN SUVmean). The total SV for each patient was also estimated on the basis of the wsVOI defined on the CT component of the PET/CT study. SUVmean variability for each patient was estimated as the absolute value of the difference between the SUVmean for the patient and the mean of the SUVmean for the whole group of patients, divided by the mean of the SUVmean for the whole group of patients. The variabilities of SUVmean calculated by the 3 methods were compared using a paired 1-tailed Wilcoxon test. Results: The mean variability for the BW, SV, and WN SUVmean was 0.16, 0.13, and 0.16, respectively. There were statistically significant differences between SV and BW SUVmean...Continue Reading

References

Jun 8, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·S Nomura, T Takano-Yamamoto
Dec 21, 2002·Critical Care : the Official Journal of the Critical Care Forum·Elise Whitley, Jonathan Ball
Dec 3, 2003·Molecular Imaging·Andreas Markus Loening, Sanjiv Sam Gambhir
Dec 14, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Frederick D GrantS Ted Treves
Sep 9, 2008·BMJ : British Medical Journal·Alan PerkinsJohn Hall
Jun 24, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Richard L WahlMartin A Lodge
Jun 9, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Stefan KrügerSven N Reske
Mar 20, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Robert K DootDavid A Mankoff
Jul 24, 2010·AJR. American Journal of Roentgenology·Michael C AdamsTerence Z Wong
Dec 1, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tao Chan
Sep 7, 2013·Medical Physics·James J HamillEmily B Martin
Feb 26, 2015·Nuclear Medicine Communications·So KubotaTomoyuki Saito
Jun 13, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Elba C EtchebehereEric M Rohren
Jul 3, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Eric M RohrenHomer A Macapinlac
Jan 1, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Pierre DecazesKhaldoun Kerrou
Apr 8, 2016·Clinical Nuclear Medicine·Giovanna CarvalhoCarlos Alberto Buchpiguel
Mar 31, 2018·Journal of Nuclear Medicine Technology·Trygve HalsneCaroline Stokke

❮ Previous
Next ❯

Citations

Feb 27, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Wouter van der BruggenDennis Vriens
Jan 12, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Paulo Schiavom Duarte, Marcelo Tatit Sapienza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Nuclear Medicine
Giovanna CarvalhoCarlos Alberto Buchpiguel
Nuclear Medicine Communications
Paula Lapa, João Pedroso de Lima
Seminars in Nuclear Medicine
M BlauM A Bender
© 2022 Meta ULC. All rights reserved