Comparison of the vasodilator action of dopamine and dopamine agonists in the renal and coronary beds of the dog

British Journal of Pharmacology
W J Lang, O L Woodman

Abstract

1 The effects of dopamine and the dopamine receptor agonists, SK&F 38393 and bromocriptine, on renal and coronary blood flow in the anaesthetized dog were examined. Dopamine was found to dilate both vascular beds, whereas SK&F 38393 increased renal blood flow but did not have any dilator activity in the coronary vasculature. Bromocriptine did not cause vasodilatation in either vascular bed. 2 The vasodilator responses to dopamine and SK&F 38393 were significantly reduced by the dopamine receptor antagonists, ergometrine or metoclopramide. 3 It is proposed that the selective action of SK&F 38393 on the renal vasculature suggests that the dopamine receptors of the renal and coronary vascular beds may be of different types.

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Jan 28, 1983·European Journal of Pharmacology·J M ArmstrongS Z Langer
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Feb 14, 2021·Biomolecules·Alejandro Olivares-HernándezJosé Pablo Miramontes-González

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