Comparison of the virulence of O:9,12 and O:4,5,12 Salmonella typhimurium his+ transductants for mice.

Infection and Immunity
M B LymanR J Roantree

Abstract

The purpose of these experiments was to determine whether qualitative differences in the O repeat unit of the lipopolysaccharide of pathogenic Salmonella species affected virulence for mice. O:4,5,12 and O:9,12 sister his+ transductants were derived from a virulent Salmonella typhimurium. Fermentation markers were introduced by transduction to differentiate these strains, and the strains were used as mixed challenge to CF1 and C57B1/6J mice. Liver and spleen cultures of the mice of various intervals after challenge indicated that the O:4,5,12 member of the nearly isogenic pair regularly multiplied to a greater extent than the O:9,12 after intraperitoneal challenge for both strains of mice. After oral challenge, there was little difference in the amount of multiplication of the O:4,5,12 and O:9,12 strains in CF1 mice, but the O:4,5,12 was the predominant strain recovered in 8 of 10 instances in the C57B1/6J mice.

References

Oct 1, 1974·Infection and Immunity·P B Carter, F M Collins
Oct 1, 1972·The Journal of Infectious Diseases·H G Robson, S I Vas
May 1, 1972·Journal of General Microbiology·R G WilkinsonB A Stocker
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Aug 1, 1967·Journal of General Microbiology·B W Nelson, R J Roantree
Feb 1, 1967·Virology·H O Smith, M Levine
Jan 1, 1953·Acta Pathologica Et Microbiologica Scandinavica·F KAUFFMANN

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Citations

Jan 1, 1980·Scandinavian Journal of Infectious Diseases. Supplementum
Nov 14, 1997·Infection and Immunity·B D JonesM A Apicella
Nov 1, 1978·Infection and Immunity·I KochanM A McCabe
Dec 1, 1978·Infection and Immunity·A W HohmannD Rowley
Feb 1, 1991·Microbial Pathogenesis·C E HormaecheB A Stocker

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