Comparison of the virulence of Trypanosoma congolense strains isolated from cattle in a trypanosomiasis endemic area of eastern Zambia

International Journal for Parasitology
J MasumuP Van den Bossche

Abstract

The virulence of 31 genetically different Trypanosoma congolense strains belonging to the Savannah subgroup and isolated from cattle at 11 sites in a trypanosomiasis endemic area of eastern Zambia was compared. Virulence testing, done in OF1 mice, revealed three virulence categories. Strains were considered extremely virulent when the median survival time ranged between 5 and 9 days. Moderately virulent strains had a median survival time between 10 and 30 days and low virulence, more than 30 days. For each strain, the prepatent period was determined and the PCV of the infected animals was measured at regular intervals. A total of six (19.4%) strains belonged to the extremely virulent category with a short prepatent period (mean 2.3+/-0.3 days), high parasitaemia, decline in PCV of 15.6+/-1.1% during the first 7 days p.i. and a short median survival time (mean 6 days). The remainder of the strains belonged to the moderate (13 strains) or low (12 strains) virulence categories with median survival times of 13 and 60 days, respectively. They had longer prepatent periods (means 3.2+/-1.6 days and 3.5+/-1.6 days for moderately virulent and strains with low virulence, respectively) and the decline in PCV was less steep (decline of 14....Continue Reading

References

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Citations

Jan 29, 2013·Parasitology Research·Hirohisa MekataKazuhiko Ohashi
Dec 4, 2009·PLoS Neglected Tropical Diseases·Liam J MorrisonAnnette MacLeod
Jan 19, 2013·The Onderstepoort Journal of Veterinary Research·Makhosazana MotloangAbdalla Latif
May 17, 2011·Veterinary Parasitology·Andy TaitAnnette Macleod
Mar 23, 2010·Trends in Parasitology·Peter Van den BosscheJérémy Bouyer
Feb 10, 2009·Trends in Parasitology·Stanny GeertsDéthié Faye
May 9, 2009·Veterinary Parasitology·J MasumuP Van den Bossche
Feb 1, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Adriana C RodriguesMarta M G Teixeira
Oct 11, 2016·Parasitology·Federica GiordaniMichael P Barrett
Sep 13, 2016·The Journal of Veterinary Medical Science·Simon Peter MusinguziNoboru Inoue
Feb 17, 2015·The Onderstepoort Journal of Veterinary Research·Makhosazana Y MotloangAbdalla A Latif
Jun 7, 2019·The Onderstepoort Journal of Veterinary Research·Abdalla A LatifChantel De Beer
Feb 16, 2021·Frontiers in Veterinary Science·Yukiko NakamuraJunya Yamagishi

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