Comparison of therapeutic effects of inhaled corticosteroids on three subtypes of cough variant asthma as classified by the impulse oscillometry system

Respiratory Research
Hiroyuki SugawaraHiroki Takahashi

Abstract

Cough variant asthma (CVA) is one of the most common causes of chronic persistent cough, and early treatment with inhaled corticosteroids (ICSs) is recommended to attenuate the inflammation and remodeling. The impulse oscillometry system (IOS) is a novel device for respiratory functional assessment that has not yet been assessed in terms of CVA. Therefore, we investigated the relationship between CVA and IOS, and the difference in therapeutic effects of ICSs among the subtype classifications by IOS. The following ICSs were randomly prescribed in daily medical care: coarse-particle ICS (fluticasone propionate [FP]), fine-particle ICS (mometasone furoate [MF]), and moderate-particle ICS (budesonide [BUD]). Treatment effects were assessed by the Leicester cough questionnaire (LCQ) and were compared among three separated subtypes based on IOS measurements: central, peripheral, and resistless. Regarding LCQ scores, in the central type, the LCQ of the MF group was significantly lower than FP and BUD. In the peripheral type, the LCQ of the FP group was significantly lower than MF and BUD. In the resistless type, the LCQ of the MF group was significantly lower than BUD. Also, IOS factors were improved by 4 weeks of therapy with ICS. Th...Continue Reading

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Citations

Feb 7, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Francesca S M TangDavid G Chapman
Sep 2, 2020·Respiratory Research·Hiroyuki SugawaraHiroki Takahashi
Oct 8, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Andrew KouriChung-Wai Chow

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Methods Mentioned

BETA
bronchoalveolar lavage
biopsy
biopsies

Software Mentioned

Excel
Excel Statistical Program
GraphPad Prism
JMP13

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