Abstract
Cough variant asthma (CVA) is one of the most common causes of chronic persistent cough, and early treatment with inhaled corticosteroids (ICSs) is recommended to attenuate the inflammation and remodeling. The impulse oscillometry system (IOS) is a novel device for respiratory functional assessment that has not yet been assessed in terms of CVA. Therefore, we investigated the relationship between CVA and IOS, and the difference in therapeutic effects of ICSs among the subtype classifications by IOS. The following ICSs were randomly prescribed in daily medical care: coarse-particle ICS (fluticasone propionate [FP]), fine-particle ICS (mometasone furoate [MF]), and moderate-particle ICS (budesonide [BUD]). Treatment effects were assessed by the Leicester cough questionnaire (LCQ) and were compared among three separated subtypes based on IOS measurements: central, peripheral, and resistless. Regarding LCQ scores, in the central type, the LCQ of the MF group was significantly lower than FP and BUD. In the peripheral type, the LCQ of the FP group was significantly lower than MF and BUD. In the resistless type, the LCQ of the MF group was significantly lower than BUD. Also, IOS factors were improved by 4 weeks of therapy with ICS. Th...Continue Reading
References
Mar 22, 1979·The New England Journal of Medicine·W M CorraoR S Irwin
Apr 1, 1992·Internal Medicine·M FujimuraT Matsuda
Jul 2, 1998·The European Respiratory Journal·A NiimiF Kuze
Oct 9, 1999·The European Respiratory Journal·Y Y KohC K Kim
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·A NiimiT Izumi
Oct 18, 2001·Pulmonary Pharmacology & Therapeutics·M D Goldman
Feb 6, 2002·Thorax·P G GibsonA Niimi
Aug 13, 2002·Chest·Chet L LeachRobert J Boudreau
Jan 4, 2003·Thorax·M FujimuraK Nishi
Apr 2, 2003·Thorax·S S BirringI D Pavord
Dec 19, 2003·The European Respiratory Journal·E OostveenUNKNOWN ERS Task Force on Respiratory Impedance Measurements
Apr 13, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Masaki FujimuraKeiichi Iwasa
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Akio NiimiKian Fan Chung
Dec 7, 2005·Respiratory Medicine·Antonio NietoAngel Mazon
Jan 24, 2006·Chest·Richard S Irwin
Mar 7, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Hisako MatsumotoMichiaki Mishima
Jan 11, 2007·Cough·Hisako MatsumotoMichiaki Mishima
Sep 25, 2007·Chest·Beno W OppenheimerKenneth I Berger
Jun 3, 2009·Pulmonary Pharmacology & Therapeutics·Masafumi YamaguchiMichiaki Mishima
Sep 25, 2009·Respiration; International Review of Thoracic Diseases·Tomoshi TakedaMichiaki Mishima
Dec 22, 2010·Lung·Peter A WilliamsonBrian J Lipworth
Jan 15, 2011·International Journal of Pharmaceutics·Thiago C CarvalhoRobert O Williams
Nov 15, 2011·Current Respiratory Medicine Reviews·Akio Niimi
Dec 20, 2011·The Journal of Allergy and Clinical Immunology·Yixin ShiSteven C George
Nov 30, 2012·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Guang-Sheng QiJin-Ming Liu
Feb 15, 2013·Allergy and Asthma Proceedings·Roberta PisiAlfredo Chetta
Dec 18, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S GonemS Siddiqui
Jul 19, 2014·The European Respiratory Journal·Arvind ManoharanBrian J Lipworth
Apr 23, 2016·Allergy & Rhinology·Yasushi ObaseTomoaki Iwanaga
May 19, 2018·Respiratory Investigation·Toshihiro Shirai
Citations
Feb 7, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Francesca S M TangDavid G Chapman
Feb 1, 2020·Scientific Reports·Frederik TrinkmannJoachim Saur
Sep 2, 2020·Respiratory Research·Hiroyuki SugawaraHiroki Takahashi
Oct 8, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Andrew KouriChung-Wai Chow