Comparison of therapeutic studies on regression of left ventricular hypertrophy

Advances in Experimental Medicine and Biology
R E Schmieder, M P Schlaich

Abstract

In numerous studies left ventricular hypertrophy has been clearly established to be a strong, blood-pressure independent risk factor for cardiovascular morbidity and mortality. In fact, increased echocardiographic left ventricular mass has been shown to predict cardiovascular complications not only in patients with hypertension, but also in the general population. Preliminary data revealed that regression of left ventricular hypertrophy indeed reduces cardiovascular complications. As a consequence, regression of left ventricular hypertrophy by drug treatment has emerged as a desirable goal in patients with echocardiographically determined left ventricular hypertrophy. These findings raised the question, whether certain antihypertensive drugs differ in their ability to reduce left ventricular mass. To resolve this issue several comparative studies and some meta-analyses have been carried out. In a meta-analysis by Dahlöf et al., comprising 109 treatment studies published until december 1990 with a total of 2357 patients, ACE-inhibitors (-15%) were most effective in reducing left ventricular mass followed by diuretics (-11.3%), calcium channel blockers (-8.5%) and beta-blockers (-8%). Reduction in left ventricular mass was mainly...Continue Reading

Citations

Sep 4, 1999·Clinical and Experimental Pharmacology & Physiology·S P McDonaldW E Hoy
Jan 3, 2007·Journal of the Renin-angiotensin-aldosterone System : JRAAS·B Dahlöf
Oct 16, 2002·Current Cardiology Reports·Erwin H Fleischmann, Roland E Schmieder

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