Comparison of three antimicrobial strategies in diabetic foot infections post-amputation

Therapeutic Advances in Infectious Disease
Samarth P ShahJennifer D Twilla

Abstract

The 2012 Infectious Disease Society of America (IDSA) guidelines recommend antimicrobial treatment of diabetic foot infections (DFIs) post-amputation, but the optimal route and duration are poorly defined. The objective of this study was to determine whether the selection of a specific antimicrobial treatment modality affected hospital and patient outcomes. This was a retrospective review of hospital admissions of adults admitted to ourhealthcare system with a primary diagnosis of DFIs post-amputation. The groups were separated into patients who received intravenous antimicrobials (IV), oral antimicrobials (PO), or no antimicrobials (NA). Outcomes included average length of stay among others. Of the 200 patients screened, 120 patients were included (IV n = 72; PO n = 20; NA n = 28). No statistically significant differences were identified in average LOS (IV = 9.97 ± 5.85, PO = 8.83 ± 7.37, NA = 9.33 ± 5.91 days; p = 0.73). However, post-operative (post-op) LOS was significantly shorter in the PO group (PO = 3.43 ± 2.56, IV = 7.34 ± 5.95, NA = 5.81 ± 4.18 days; p = 0.0001). The results of our study indicate that a PO antimicrobial treatment strategy post amputation for DFIs has the potential to decrease post-op LOS without incre...Continue Reading

References

Mar 31, 1999·Diabetes Care·S D RamseyE H Wagner
May 10, 2003·Lancet·William J Jeffcoate, Keith G Harding
May 20, 2004·Diabetes/metabolism Research and Reviews·Benjamin A Lipsky, UNKNOWN International consensus group on diagnosing and treating the infected diabetic foot
Jan 13, 2005·JAMA : the Journal of the American Medical Association·Nalini SinghBenjamin A Lipsky
Oct 5, 2007·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·U SadatK Varty
Jan 30, 2008·Diabetes Care·Zachary T Bloomgarden
Nov 16, 2010·Expert Review of Anti-infective Therapy·Mark A Kosinski, Benjamin A Lipsky
May 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin A Lipsky Infectious Diseases Society of America
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Christopher W SeymourDerek C Angus
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus

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Methods Mentioned

BETA
amputation
amputations

Software Mentioned

SPSS

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