PMID: 8973696Dec 1, 1996Paper

Comparison of three assays for total serum prostate-specific antigen and percentage of free prostate-specific antigen in predicting prostate histology

Urology
C G RoehrbornF H Wians

Abstract

To determine the statistical performance of three different assays for prostate specific antigen (PSA) and the percentage of free PSA with respect to the differentiation of histologic benign prostatic hyperplasia (BPH) and prostate cancer in men who underwent surgical removal of prostate tissue. Serum of 86 men scheduled for prostate surgery (transurethral resection of the prostate [TURP], simple open prostatectomy, radical prostatectomy, cystoprostatectomy) was frozen and subjected to measurement in batches using three different assays for total PSA (Hybritech Tandem-E, Abbott IMx, Tosoh AIA-600) and free PSA by the Hybritech method after a single freeze-thaw cycle. The histologic diagnosis of the removed tissue (35 BPH and 51 cancer) was used as a "gold standard" for classification of disease status. Sensitivity, specificity, positive and negative predictive values, and diagnostic efficiency were calculated for the three total PSA assays and the free/total PSA ratios for the entire cohort and subsets. Receiver-operating characteristic (ROC) curve analysis was used to compare the performance of the assays and ratios. Mean and median total PSA values differed slightly between the three assays for all patients, and for those wit...Continue Reading

Citations

Jul 29, 1996·International Journal of Cancer. Journal International Du Cancer·C StephanS A Loening
Mar 15, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Monte S Willis, Frank H Wians
Nov 6, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·R Daher, M Beaini
Sep 26, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Carsten StephanKlaus Jung
Oct 14, 2006·Current Opinion in Urology·U H StenmanP Wu
Apr 15, 1999·Seminars in Cancer Biology·U H StenmanP Finne
Mar 5, 2005·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Maria de F FigueirêdoTalapala G Naidu

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