PMID: 6103706Apr 1, 1980Paper

Comparison of three benzodiazepines for oral premedication in minor gynaecological surgery

British Journal of Anaesthesia
C G MaleJ M Gibbs

Abstract

Diazepam 10 and 20 mg, lorazepam 2.5 and 5.0 mg, flunitrazepam 1 and 2 mg, and a placebo, were compared in a randomized double-blind controlled trial as oral premedication for 210 patients undergoing minor gynaecological surgery. Flunitrazepam 1 mg and lorazepam 2.5 mg were superior to placebo (P less than 0.001 and P less than 0.05 respectively) in relieving patient anxiety when assessed by a trained observer 60 min after premedication. Flunitrazepam 1 mg also produced more drowsiness (P less than 0.01) than the placebo. Comparisons of other low-dose benzodiazepine groups with the placebo, and of the large dose with the small dose of each drug revealed no significant changes in anxiolysis or drowsiness. Dizziness and prolonged drowsiness were not apparent with low-dose flunitrazepam. The data suggests that flunitrazepam 1 mg offers advantages over placebo, diazepam 10 mg and lorazepam 2.5 mg for routine oral premedication in minor gynaecological surgery.

Citations

Sep 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J B Dyck, F Chung
Sep 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·V K KontinenJ Sarvela
Sep 1, 1985·Canadian Anaesthetists' Society Journal·D P Cartwright
Feb 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P M SaccomannoA N Sandler
Mar 1, 1991·Journal of Veterinary Pharmacology and Therapeutics·W W MuirR Bednarski
Sep 1, 1992·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·P M Loeffler
Jan 1, 1986·Acta Psychiatrica Scandinavica. Supplementum·J Kanto
Jan 1, 1981·Anaesthesia·A P BeecheyC Studd
Feb 1, 1985·Acta Anaesthesiologica Scandinavica·M S Hüttel, U Bang
May 1, 1987·Acta Anaesthesiologica Scandinavica·B HofstadP A Steen
May 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T H Madej, R T Paasuke

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