Comparison of three commercial one-dose porcine circovirus type 2 (PCV2) vaccines in a herd with concurrent circulation of PCV2b and mutant PCV2b

Veterinary Microbiology
Jiwoon JeongChanhee Chae

Abstract

Porcine circovirus associated disease (PCVAD) occurred in a farm where pigs had been routinely vaccinated with a commercial PCV2a vaccine. A mutant PCV2b (mPCV2b) was isolated from pigs with PCVAD, perhaps implying a perceived vaccine failure. The objective of this study was to determine and compare the efficacy of 3 one-dose PCV2a vaccines of varying antigen type and dose in the same pig farm with concurrent PCV2b and mPCV2b infection based on clinical (average daily weight gain; ADWG), virological (evidence of viremia), immunological (presence of PCV2-specific neutralizing antibody; NA and interferon-γ secreting cells; IFN-γ-SC), and pathological (lymphoid lesion and PCV2 antigen score within lesion) evaluation. Regardless of which commercial PCV2a vaccine was used, vaccinated animals improved ADWG, and reduced the amount of PCV2b and mPCV2b load in the blood compared to unvaccinated animals. The vaccination of piglets at 3 weeks of age effectively induced higher levels of PCV2b- and mPCV2b-specific NA and IFN-γ-SC compared to unvaccinated animals. A reduction in mPCV2b load in the blood coincided with the appearance of both mPCV2b-specific NA and IFN-γ-SC in the vaccinated animals. The microscopic lymphoid lesions and PCV2-a...Continue Reading

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Citations

Oct 23, 2016·Veterinary Microbiology·Zahra AfghahSheela Ramamoorthy
Jul 25, 2020·Translational Animal Science·Jordan T GebhardtSteve C Henry
May 7, 2019·Transboundary and Emerging Diseases·Aleksandra WoźniakTomasz Stadejek
Jul 3, 2019·Veterinary Sciences·Oleksandr KolyvushkoSheela Ramamoorthy
Jul 19, 2020·Animals : an Open Access Journal From MDPI·Laurynas VadopalasElena Bartkiene
Mar 13, 2021·Transboundary and Emerging Diseases·Gonzalo López-LorenzoJosé Manuel Díaz-Cao

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