Comparison of three different regimens against Helicobacter pylori as a first-line treatment: A randomized clinical trial

Bosnian Journal of Basic Medical Sciences
Ayse KefeliOzlem Tanas

Abstract

Treatments with bismuth-containing quadruple therapy (QT), sequential therapy (ST), or concomitant therapy (CT) have been proposed as empirical first-line regimens for Helicobacter pylori. We compared the efficacy and tolerability of 10 days bismuth-containing quadruple QT, 10 days ST, and 10 days CT with as first-line treatments for H. pylori in a randomized crossover study. The subjects were randomly divided into three groups. The first 130 patients were treated with rabeprazole, bismuth potassium citrate, metronidazole, and tetracycline for 10 days. The second 130 patients in the sequential group were treated with rabeprazole and amoxicillin for 5 days, and then rabeprazole, clarithromycin, and metronidazole for an additional 5 days. The last 130 patients in the concomitant group were treated with rabeprazole, amoxicillin, clarithromycin, and metronidazole for 10 days. H. pylori eradication was confirmed by urea breath test at 6 weeks. The primary outcome was eradication rates of first-line treatment by intention to treat and per protocol (PP) analyzes. There was no difference between the average ages and the male/female ratio of the groups. The PP analysis was performed on 121, 119, and 118 patients in the QT, ST, and CT gr...Continue Reading

Citations

Jan 21, 2021·Gut and Liver·Hye-Kyung JungUNKNOWN Korean College of Helicobacter and Upper Gastrointestinal Research
Jun 8, 2021·The Korean Journal of Internal Medicine·Hye-Kyung JungUNKNOWN Korean College of Helicobacter and Upper Gastrointesinal Research

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