Comparison of three different tools for prediction of seminal vesicle invasion at radical prostatectomy.

European Urology
Giovanni LughezzaniPierre I Karakiewicz

Abstract

Statistical prediction tools are increasingly common, but there is considerable disagreement about how they should be evaluated. Three tools--Partin tables, the European Society for Urological Oncology (ESUO) criteria, and the Gallina nomogram--have been proposed for the prediction of seminal vesicle invasion (SVI) in patients with clinically localized prostate cancer who are candidates for a radical prostatectomy. Using different statistical methods, we aimed to determine which of these tools should be used to predict SVI. The independent validation cohort consisted of 2584 patients treated surgically for clinically localized prostate cancer at four North American tertiary care centers between 2002 and 2007. Robot-assisted laparoscopic radical prostatectomy. Primary outcome was the presence of SVI. Traditional (area under the receiver operating characteristic [ROC] curve, calibration plots, the Brier score, sensitivity and specificity, positive and negative predictive value) and novel (decision curve analysis and predictiveness curves) statistical methods quantified the predictive abilities of the three models. Traditional statistical methods (ie, ROC plots and Brier scores) could not clearly determine which one of the three S...Continue Reading

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Citations

May 15, 2012·European Urology·Michael W Kattan, Thomas A Gerds
Jun 2, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathleen F KerrHolly Janes
Jan 20, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Alberto MartiniAshutosh K Tewari
Mar 24, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M ChasserayU Schick

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