Abstract
Immunohistochemical staining against thyroid transcription factor 1 (TTF-1) is often used to distinguish lung adenocarcinoma from squamous cell carcinoma and pulmonary metastasis. TTF-1 expression was examined using the antibody clones 8G7G3/1, SPT24, and SP141 on tissue microarrays from 665 cases of resected lung cancers and 428 pulmonary metastases. Most lung adenocarcinomas, 89%, 93%, and 93%, were positive with TTF-1 clones 8G7G3/1, SPT24, and SP141, respectively. The corresponding figures for lung squamous cell carcinomas were 0%, 6%, and 8%. In total, five (2%), 19 (7%), and 21 (8%) of the pulmonary metastases from colorectal adenocarcinomas were positive with clones 8G7G3/1, SPT24, and SP141, respectively. Other TTF-1-positive pulmonary metastases (n = 8) were thyroid, urothelial, pancreatic, small bowel, and cervix carcinomas. TTF-1 expression in lung cancer and pulmonary metastases differs between clones, with 8G7G3/1 being more specific but less sensitive compared with SPT24 and SP141.
References
Mar 28, 2002·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·J ManjerG Berglund
May 25, 2002·Scandinavian Journal of Public Health·Jonas ManjerGöran Berglund
Mar 21, 2003·Virchows Archiv : an International Journal of Pathology·A AlkushiC B Gilks
Sep 29, 2004·Journal of Clinical Pathology·J ZamecnikR Kodet
Apr 30, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Eva CompératSaphie Camilleri-Broët
May 10, 2006·Histopathology·A D GrahamD M Salter
May 30, 2006·Journal of Clinical Pathology·D PenmanF Roberts
Jun 15, 2007·Virchows Archiv : an International Journal of Pathology·Malcolm Galloway, Rosalind Sim
Jul 31, 2007·Journal of Clinical Pathology·Tony Kiat-Hon LimPuay-Hoon Tan
Dec 7, 2007·The American Journal of Surgical Pathology·Koushan SiamiMichael T Deavers
Dec 3, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Paul J ZhangVirginia A Livolsi
Sep 11, 2009·Human Pathology·Justin A BishopPeter B Illei
Nov 6, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Andres MatosoLi J Wang
Dec 17, 2009·Human Pathology·Sawako FujiwaraYasushi Yatabe
Jan 1, 2010·Applied Immunohistochemistry & Molecular Morphology : AIMM·Bo XuThaer Khoury
Nov 26, 2010·The American Journal of Surgical Pathology·Judith RobensStuart J Schnitt
Feb 18, 2011·Applied Immunohistochemistry & Molecular Morphology : AIMM·Marianne Højsgaard KristensenMogens Vyberg
Jul 21, 2011·Histopathology·Aya SakuraiYasushi Yatabe
Aug 16, 2011·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·J YeH Xu
Feb 1, 2012·Archives of Pathology & Laboratory Medicine·Bradley M TurnerJaishree Jagirdar
Apr 26, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Nelson G Ordóñez
Jun 15, 2013·American Journal of Clinical Pathology·Hans BrunnströmMaria Planck
Dec 18, 2013·Histopathology·Gabriela GremelFredrik Pontén
Jan 15, 2014·The American Journal of Surgical Pathology·Lea F SurreyEmma E Furth
Apr 15, 2015·The American Journal of Surgical Pathology·Kyuichi KadotaWilliam D Travis
Oct 18, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Lena TranHans Brunnström
Oct 16, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Sarah M ChoiPaul J Zhang
Feb 14, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Patrick MickeHans Brunnström
Mar 30, 2017·Diagnostic Pathology·Kajsa Ericson-LindquistHans Brunnström
Sep 16, 2017·Histopathology·Jeong Mo BaeGyeong Hoon Kang
Citations
Feb 6, 2019·Scientific Reports·Patrick MickeHans Brunnström
Apr 3, 2019·Der Pathologe·A Warth, L Fink
Jan 9, 2020·Archives of Pathology & Laboratory Medicine·Johan StaafHans Brunnström
Jan 27, 2021·Journal of Surgical Oncology·Halla VidarsdottirHans Brunnström
Feb 7, 2021·Journal of Clinical Pathology·Kajsa Ericson LindquistHans Brunnström
Oct 9, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Aya Miyagawa-HayashinoEiichi Konishi
Nov 6, 2018·Human Pathology·Halla VidarsdottirHans Brunnström