PMID: 11340595May 8, 2001Paper

Comparison of three joint simulator wear debris isolation techniques: acid digestion, base digestion, and enzyme cleavage

Journal of Biomedical Materials Research
S NiedzwieckiL Pruitt

Abstract

Quantification of ultrahigh molecular weight polyethylene (UHMWPE) wear debris remains a challenging task in orthopedic device analysis. Currently, the weight loss method is the only accepted practice for quantifying the amount of wear generated from a PE component. This technique utilizes loaded soak controls and weight differences to account for polymeric material lost through wear mechanisms. This method enables the determination of the amount of wear in the orthopedic device, but it provides no information about debris particulate size distribution. In order to shed light on wear mechanisms, information about the wear debris and its size distribution is necessary. To date, particulate isolation has been performed using the base digestion technique. The method uses a strong base, ultracentrifugation, and filtration to digest serum constituents and to isolate PE debris from sera. It should be noted that particulate isolation methods provide valuable information about particulate size distribution and may elucidate the mechanisms of wear associated with polymeric orthopedic implants; however, these techniques do not yet provide a direct measure of the amount of wear. The aim of this study is to present alternative approaches t...Continue Reading

References

Jan 1, 1995·Journal of Biomedical Materials Research·P CampbellH C Amstutz
Jan 1, 1996·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·P CampbellH C Amstutz
Jan 1, 1997·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·G W StachowiakP Campbell
Jan 1, 1997·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·P A RevellA Kobayashi
Jul 22, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·B S RamamurtiW H Harris
Mar 26, 1999·Journal of Biomaterials Science. Polymer Edition·S SteaA Pizzoferrato
May 20, 1999·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·A A BesongJ Fisher

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Citations

Oct 12, 2012·Der Orthopäde·J P KretzerS Utzschneider
Dec 4, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Thomas M GruppWilhelm Blömer
Apr 26, 2013·Journal of Materials Science. Materials in Medicine·Carmen ZietzRainer Bader
Nov 20, 2013·Journal of Materials Science. Materials in Medicine·A C PaulusS Utzschneider
Aug 13, 2013·Acta Biomaterialia·Christian SchröderJ Philippe Kretzer
Mar 1, 2012·Journal of Shoulder and Elbow Surgery·Zachary M VaupelJ Michael Wiater
Sep 23, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jörn ReindersJan Philippe Kretzer
Dec 3, 2014·Acta Biomaterialia·Jörn ReindersJan Philippe Kretzer
Apr 14, 2015·BioMed Research International·Alexander Christoph PaulusSandra Utzschneider
Jun 22, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jana MarkhoffRainer Bader
Jul 13, 2014·Journal of Materials Science. Materials in Medicine·Jörn ReindersJan Philippe Kretzer
Feb 25, 2014·Journal of Materials Science. Materials in Medicine·S UtzschneiderV Jansson
Jun 7, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Thomas M GruppWilhelm Blömer
Oct 22, 2008·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·J P ShorezN Walter
Jun 19, 2004·The International Journal of Artificial Organs·S AffatatoA Toni
Jun 4, 2013·Journal of Applied Biomaterials & Functional Materials·Antonio GiganteMonica Mattioli-Belmonte

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