Comparison of three mathematical models for predicting the risk of additional axillary nodal metastases after positive sentinel lymph node biopsy in early breast cancer

The British Journal of Surgery
Y MoghaddamMohammed R S Keshtgar

Abstract

Women with breast cancer and a positive axillary sentinel lymph node (SLN) are recommended to undergo complete axillary lymph node dissection; however, further nodal disease is not always present. Mathematical models have been constructed to determine the risk of metastatic disease; three of these were evaluated independently. Data from 108 women with breast cancer who had a positive SLN biopsy and completion axillary lymph node dissection were used. Measurements of additional parameters over those usually determined (such as size of SLN metastasis) were assessed under the supervision of two pathologists. These data were used to determine the predicted risk of non-SLN metastases using three mathematical models (from Memorial Sloan-Kettering Cancer Center (MSKCC), Cambridge University and Stanford University) and a comparison made with the observed findings. Analyses were made using the area under the receiver operating characteristic (ROC) curve (AUC). Some 53 (49.1 per cent) of 108 patients had a positive non-sentinel axillary lymph node metastasis. The AUC values were 0.63, 0.72 and 0.67 for the MSKCC, Cambridge and Stanford nomograms respectively. This independent comparison found no significant difference between the models...Continue Reading

References

Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A E GiulianoR Statman
Oct 1, 1998·The New England Journal of Medicine·D KragP Beitsch
Mar 2, 1999·Journal of the National Cancer Institute·U VeronesiD Scarpa
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T F HackP Goss
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C ReynoldsB J Czerniecki
May 18, 2001·Archives of Surgery·S L WongUNKNOWN University of Louisville Breast Cancer Sentinel Lymph Node Study Group
Nov 27, 2001·American Journal of Surgery·S F AbdessalamW E Burak
Mar 22, 2002·The Lancet Oncology·Mohammed R S Keshtgar, Peter J Ell
Apr 12, 2002·American Journal of Surgery·Ulka SachdevSteven Brower
Oct 3, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H MignotteA Bremond
Aug 9, 2003·The New England Journal of Medicine·Umberto VeronesiRoberto Gennari
Dec 16, 2003·Breast Cancer Research and Treatment·Vincent van ItersonKarl von Smitten
Dec 25, 2003·Journal of Clinical Pathology·F J FlemingA D K Hill
Mar 11, 2004·The Breast Journal·David J DabbsRonald Johnson
May 26, 2004·The American Surgeon·Todd M Tuttle
Oct 7, 2004·Japanese Journal of Clinical Oncology·Gábor CserniMihály Svébis
Jan 12, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M H K LeideniusP S Heikkilä
Apr 6, 2005·The British Journal of Surgery·P SchrenkS Redtenbacher
May 14, 2005·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Isabel Peixoto CallejoJ Meneses e Sousa
Jul 16, 2005·Annals of Surgical Oncology·Michelle C SpechtKimberly J Van Zee
Sep 2, 2005·Annals of Surgery·Donald L MortonUNKNOWN Multicenter Selective Lymphadenectomy Trial Group
Nov 15, 2006·Annals of Surgical Oncology·Marjolein L SmidtTheo Wobbes
May 22, 2007·American Journal of Surgery·Riccardo PonzonePiero Sismondi
Mar 12, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lee K TanHiram S Cody
Aug 14, 2009·The New England Journal of Medicine·Maaike de BoerVivianne C G Tjan-Heijnen

❮ Previous
Next ❯

Citations

Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Antonio PiñeroUNKNOWN Members of the Group for Senologic Studies of the Spanish Society of Senology
Dec 7, 2013·BMC Surgery·Alessandro CappellaniMassimiliano Berretta
Jan 12, 2013·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Tatsunari SasadaHideki Ohdan
Feb 26, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J NathA P Corder
Mar 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Bulent KocaYuksel Bek
Aug 3, 2013·Physical Therapy·Mary Lou Galantino, Nicole L Stout
Jul 19, 2017·The British Journal of Surgery·L DihgeL Rydén

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Therapeutic Approaches

Several different therapeutic approaches are used to treat breast cancer. These include chemotherapy, hormonal therapy, targeted therapy, and Immunotherapy. Discover the latest research on breast cancer therapeutic approaches here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.