PMID: 6104182Jun 28, 1980Paper

Comparison of three methods of central-nervous-system prophylaxis in childhood acute lymphoblastic leukaemia

Lancet
D M GreenE Frei

Abstract

A retrospective comparison was made of three methods of central-nervous-system prophylaxis in childhood acute lymphoblastic leukaemia; (1) intrathecal methotrexate only; (2) intermediate-dose methotrexate infusion and intrathecal methotrexate and, (3) 2400 rads cranial irradiation and intrathecal methotrexate. The incidence of primary meningeal relapse was statistically significantly lower in both standard-risk patients (age grear than 24 months and less than or equal to 120 months white-cell count less than 20,000) and increased-risk patients (age less than or equal to 24 months or greater than 120 months and/or white-cell count greater than 20,000) whose central-nervous-system prophylaxis included cranial irradiation. The disease-free and overall survival of irradiated increased-risk patients was significantly better than that of unirradiated increased-risk patients. The disease-free survival of standard-risk patients who received intermediate-dose methotrexate was statistically superior to that of the remaining standard-risk patients. There were no significant differences in overall survival between the three groups of standard-risk patients.

References

Jan 29, 1976·The New England Journal of Medicine·I TsukimotoB C Lampkin
Jul 1, 1978·Neurology·C J CrosleyM Nigro
Nov 1, 1978·Cancer·R J AurC Mason
Sep 1, 1977·Archives of Disease in Childhood·M A GribbinJ M Chessells
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S F SchlossmanJ L Strominger
Aug 1, 1967·Archives of Disease in Childhood·R M Hardisty, P M Norman

❮ Previous
Next ❯

Citations

Jan 1, 1996·Investigational New Drugs·S M Blaney, D G Poplack
Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·R LudwigW E Brandeis
Jul 1, 2007·Current Hematologic Malignancy Reports·Paul S Gaynon
Apr 1, 1984·European Journal of Cancer & Clinical Oncology·P Seeldrayers, J Hildebrand
Jan 1, 1989·International Journal of Radiation Oncology, Biology, Physics·S J Elyan, M V Williams
Jul 1, 1995·European Journal of Cancer. Part B, Oral Oncology·A L SonisN J Tarbell
Jun 18, 1981·The New England Journal of Medicine·J L MissetJ S Horoszewicz
Apr 1, 1993·Postgraduate Medical Journal·B L PriestleyA Gibson
May 1, 1987·The British Journal of Radiology·M V Williams
Jul 1, 1988·Current Problems in Cancer·W A Bleyer, T N Byrne
Nov 1, 1995·Pediatric Hematology and Oncology·O B Eden
Mar 1, 1988·Pediatric Annals·C A Diamond, K K Matthay
Oct 1, 1985·Clinical EEG (electroencephalography)·C M EpsteinA H Ragab
Nov 1, 1982·Drug Intelligence & Clinical Pharmacy·W E EvansW R Crom
Jan 1, 1985·Medical Oncology and Tumor Pharmacotherapy·N TubianaJ P Cano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.